© 2003

Molecular Biology of Drug Addiction

  • Rafael Maldonado

Table of contents

  1. Front Matter
    Pages i-x
  2. Opioid Addiction

    1. Front Matter
      Pages 1-1
    2. Brigitte L. Kieffer, Frédéric Simonin
      Pages 3-25
    3. Theo Mantamadiotis, Günther Schütz, Rafael Maldonado
      Pages 27-36
    4. Lisa M. Monteggia, Eric J. Nestler
      Pages 37-44
    5. Thomas Koch, Stefan Schulz, Volker Höllt
      Pages 45-60
    6. Florence Noble, Bernard P. Roques
      Pages 61-75
  3. Psychostimulant Addiction

    1. Front Matter
      Pages 77-77
    2. Toni S. Shippenberg, Vladimir I. Chefer
      Pages 107-132
    3. Michela Marinelli, Pier Vincenzo Piazza
      Pages 133-159
  4. Cannabinoid Addiction

  5. Alcohol and Nicotine Addiction

    1. Front Matter
      Pages 247-247
    2. Christopher L. Cunningham, Tamara J. Phillips
      Pages 263-294

About this book


Recent advances in molecular biotechnology have created powerful new models to clarify the neurobiological mechanisms involved in drug addiction. In Molecular Biology of Drug Addiction, leading authorities extensively survey these advances in a comprehensive multidisciplinary review of the most relevant molecular, genetic, and behavioral approaches used to investigate the neurobiological basis of drug addiction. In their exploration of the latest findings on opioid, psychostimulant, cannabinoid, alcohol, and nicotine addiction, the authors provide fresh insights into the genetic basis of drug addiction and the new therapeutic perspectives these have opened. They describe the technology available to generate conditional knockout mice and show how these mice can reveal the molecular basis of opioid, psychostimulant, and cannabinoid addiction. They also review the different behavioral models available to evaluate drug reward effects and analyze the genes involved in alcohol dependence.
State-of-the-art and multidisciplinary, Molecular Biology of Drug Addiction offers neuro- and pharmaceutical scientists a clear understanding of a vast and complex literature, illuminating the decisive progress that has recently occurred and outlining the direction of future research on addictive processes.


biology development gene expression genes molecular biology molecular mechanisms

Editors and affiliations

  • Rafael Maldonado
    • 1
  1. 1.Laboratory of Neuropharmacology Health and Life Sciences SchoolUniversitat Pompeu FabraBarcelonaSpain

Bibliographic information

  • Book Title Molecular Biology of Drug Addiction
  • Editors Rafael Maldonado
  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-1-58829-060-1
  • Softcover ISBN 978-1-61737-330-5
  • eBook ISBN 978-1-59259-343-9
  • Edition Number 1
  • Number of Pages X, 346
  • Number of Illustrations 3 b/w illustrations, 0 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
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"I found this text to be a wonderful compilation...each chapter highlighted the use of recently established techniques to provide an improved understanding of the role of specific membrane transport pathways, hormone receptors, intracellular signaling pathways and even circulating hormone and drug levels deep within the brain." -Pharmaceutical Research