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© 2003

Myasthenia Gravis and Related Disorders

  • Henry J. Kaminski
Book

Part of the Current Clinical Neurology book series (CCNEU)

Table of contents

  1. Front Matter
    Pages i-x
  2. Jon M. Lindstrom
    Pages 15-52
  3. Bianca M. Conti-Fine, Brenda Diethelm-Okita, Norma Ostlie, Wei Wang, Monica Milani
    Pages 53-91
  4. Jan B. M. Kuks, Hans J. G. H. Oosterhuis
    Pages 93-113
  5. Robert B. Daroff
    Pages 115-128
  6. Alexander Marx, Philipp Stroebel
    Pages 129-148
  7. Henry J. Kaminski
    Pages 197-221
  8. Jose Americo M. Fernandes Filho, Jose I. Suarez
    Pages 223-234
  9. Alfred Jaretzki III
    Pages 235-267
  10. C. Michel Harper, Vanda A. Lennon
    Pages 269-291
  11. Ian Hart, Angela Vincent
    Pages 293-307
  12. Suraj A. Muley, Christopher M. Gomez
    Pages 309-326
  13. James F. Howard Jr.
    Pages 327-354
  14. Robert H. Paul, James M. Gilchrist
    Pages 355-371
  15. Back Matter
    Pages 373-396

About this book

Introduction

Myasthenia gravis, the best understood autoimmune disorder, serves as a model not only for study of the pathogenesis and treatment of all autoimmune diseases, but also for understanding synaptic function. In Myasthenia Gravis and Related Disorders, Henry J. Kaminski, MD, and an international panel of expert clinicians and leading scientists comprehensively review the clinical and basic science of this disease and its relatives, including acquired neuromyotonia and Lambert-Eaton syndrome. For the clinician, the book offers a rich portrait of the wide range of signs and symptoms that make these diseases difficult to diagnose. Replete with beautiful illustrations that carry the discussion well beyond the typical textbook, the authors review in depth the available diagnostic methods and their limitations, offer practical treatment recommendations based on years of experience, and discuss several promising treatment strategies now emerging. For the basic scientist, the text illuminates neuromuscular structure and function (the site of autoimmune pathology) and describes in detail the acetylcholine receptor (the central target of pathology in myasthenia gravis).
Authoritative and insightful, Myasthenia Gravis and Related Disorders follows this difficult illness from molecule to patient adaptation to illness, translating sophisticated evidence-based medicine into approaches directly useful in the doctor's office for effective patient diagnosis and treatment.

Keywords

antibody diseases pathogenesis pathology pathophysiology physiology

Editors and affiliations

  • Henry J. Kaminski
    • 1
  1. 1.Departments of Neurology and Neurosciences, University Hospitals of Cleveland, Louis Stokes Cleveland Veterans Affairs Medical CenterCase Western Reserve UniversityClevelandUSA

Bibliographic information

  • Book Title Myasthenia Gravis and Related Disorders
  • Editors Henry J. Kaminski
  • Series Title Current Clinical Neurology
  • DOI https://doi.org/10.1007/978-1-59259-341-5
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-1-58829-058-8
  • Softcover ISBN 978-1-4757-5942-6
  • eBook ISBN 978-1-59259-341-5
  • Edition Number 1
  • Number of Pages X, 396
  • Number of Illustrations 34 b/w illustrations, 3 illustrations in colour
  • Topics Neurology
  • Buy this book on publisher's site
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Reviews

"The book covers the physiology of the neuromuscular junction and of the ACR structure with detailed illustrations. There are extensive dissertations on the immunopathogenesis of myasthenia gravis, on the different immunogenetic properties of different thymona types, and finally on the different clinical presentations and therapeutic options. An entire chapter is devoted to when thymectomy is necessary and how it is performed. The chapter on myasthenia gravis crisis is concise and informative. This is a well organized, comprehensive book with abundant up-to-date references. It belongs in the library of any neurologist involved in the care of neuromuscular junction disorders." -Doody's Health Sciences Book Review Journal

"...a well rounded book. I think that neurologists in training and general neurologists wanting a refresher course could do a lot worse then read this text. I would certainly recommend it." - Brain: A Journal of Neurology

"Primarily this book will appeal to neurologists, clinical neurophysiologists, and neuroanaesthetists who will find it useful for their everyday clinical practice; researchers of neuromuscular junction disorders will also find the book interesting. This book is an up-to-date and valuable source of information on myasthenia and related disorders." -The Lancet

"Generally, the chapters are well-written, illustrations are appropriate, and the twenty-first century well represented in the references. The book is useful and up-to-date summary of all aspects of MG and its related disorders." -Muscle & Nerve

"This book is strongly recommended to clinicians and researchers dealing with neuromuscular disorders (and to thoracic surgeons performing thymectomy)." -Journal of Neurology, Neurosurgery, and Psychiatry