Innate Immunity

  • R. Alan B. Ezekowitz
  • Jules A. Hoffmann

Part of the Infectious Disease book series (ID)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Plant Immunity

    1. Front Matter
      Pages 1-2
    2. Jonathan Cohn, Gregory B. Martin
      Pages 3-26
    3. Jeffrey G. Ellis, David A. Jones
      Pages 27-45
  3. Invertebrate Host Defense Immunity

    1. Front Matter
      Pages 59-60
    2. Ellen V. Rothenberg, Eric H. Davidson
      Pages 61-87
    3. Philippe Bulet, Maurice Charlet, Charles Hetru
      Pages 89-107
    4. Shun-ichiro Kawabata, Tsukasa Osaki, Sadaaki Iwanaga
      Pages 109-125
    5. Mika Rämet, Alan Pearson, Kati Baksa, Asha Harikrishnan
      Pages 127-135
    6. Julien Royet, Marie Meister, Dominique Ferrandon
      Pages 137-153
    7. Elena A. Levashina, Stéphanie Blandin, Luis F. Moita, Marie Lagueux, Fotis C. Kafatos
      Pages 155-173
  4. Mammalian Host Defenses: Pattern Recognition Receptors

    1. Front Matter
      Pages 175-176
    2. Tsuneyasu Kaisho, Shizuo Akira
      Pages 177-189
    3. Thiruvamoor P. Ramkumar, Djilali Hammache, Philip D. Stahl
      Pages 191-204
    4. Erika C. Crouch, Jeffrey A. Whitsett
      Pages 205-229
    5. Thilo Stehle, Mykol Larvie
      Pages 231-253
    6. Peter S. Tobias
      Pages 255-265
  5. Mammalian Host Defenses: Links Between Innate and Adaptive Immunity

    1. Front Matter
      Pages 267-268
    2. Cory M. Hogaboam, Steven L. Kunkel
      Pages 269-286
    3. Tomas Ganz, Robert I. Lehrer
      Pages 287-303
    4. Mihaela Gadjeva, Admar Verschoor, Michael C. Carroll
      Pages 305-319
    5. David M. Underhill
      Pages 341-359
    6. Joshua A. Boyce, K. Frank Austen
      Pages 361-385
    7. D. Branch Moody
      Pages 387-402
  6. Back Matter
    Pages 403-410

About this book


Humans share a common template for innate immunity-the first-line defense that serves to limit infection immediately after exposure to microorganisms-with life forms as diverse as flowering plants and insects. In Innate Immunity, leading basic researchers explore host-pathogen interactions across an evolutionary spectrum to elucidate the origins of the human defense system against infection. Bringing together the latest research in the field, the authors review four significant research areas: plant immunity, invertebrate host defense immunity, pattern recognition receptors in mammalian host defense, and the links between innate and adaptive immunity in mammals. They find that the similarities among insect, plant, and mammalian immunological systems shed light on the complex mechanisms involved in adaptive immunity, thereby increasing our understanding of mammalian host defense. Their description of various systems, pathways, molecules, and proteins engaged in the process of host defense suggests that innate and adaptive immunity can no longer be seen as two different systems, but rather as working in tandem to surround and destroy foreign agents that enter the body. The authors also discuss those templates of innate immunity found in primitive systems that are now driving most novel research on human innate immunity.
Innovative and cutting-edge, Innate Immunity demonstrates new ways to explore this system in plants, invertebrates, and mammals, and, by illuminating the dynamic interplay between infectious agents and host defense, clearly reveals the potential for improved therapies to treat infectious diseases.


Chemokine infection innate immunity proteins resistance

Editors and affiliations

  • R. Alan B. Ezekowitz
    • 1
    • 2
  • Jules A. Hoffmann
    • 3
  1. 1.Laboratory of Developmental ImmunologyMassachusetts General HospitalBostonUSA
  2. 2.Department of PediatricsHarvard Medical SchoolBostonUSA
  3. 3.Institute of Molecular and Cellular BiologyCNRSStrasbourgFrance

Bibliographic information

Industry Sectors
Health & Hospitals