Cytokines and Chemokines in Infectious Diseases Handbook

  • Malak Kotb
  • Thierry Calandra

Part of the Infectious Disease book series (ID)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction: Cytokine Biology Relevant to Infectious Diseases

  3. Cytokines in Infectious Diseases

    1. Front Matter
      Pages 7-7
    2. Graham Lord
      Pages 9-22
  4. Cytokines in Gram-Negative Infections

  5. Cytokines in Gram-Positive Infections

    1. Front Matter
      Pages 75-75
    2. Anna Norrby-Teglund, Malak Kotb
      Pages 77-92
    3. Michael S. Rolph, Stefan H. E. Kaufmann
      Pages 109-119
  6. Cytokines in Mycobacterial Infections

    1. Front Matter
      Pages 121-121
    2. Claire Fieschi, Stéphanie Dupuis, Capucine Picard, Jean-Laurent Casanova
      Pages 151-161
    3. Elizabeth Pereira Sampaio, Milton Ozorio Moraes, M. Cristina Vidal Pessolani, Euzenir Nunes Sarno
      Pages 163-186
  7. Cytokines in Other Bacterial Infections

    1. Front Matter
      Pages 187-187
    2. Abbie L. Meyer, Brigitte T. Huber
      Pages 189-199
    3. Peter Kragsbjerg, Hans Holmberg
      Pages 201-211
  8. Cytokines in Fungal Infections

    1. Front Matter
      Pages 213-213
    2. Emmanuel Roilides, Joanna Filioti, Cristina Gil-Lamaignere
      Pages 215-226
  9. Cytokines in Parasitic Infections

    1. Front Matter
      Pages 243-243
    2. Fabienne Tacchini-Cottier, Geneviève Milon, Jacques A. Louis
      Pages 245-258
  10. Cytokines in Viral Infections

    1. Front Matter
      Pages 283-283
    2. Grant McFadden
      Pages 285-299
    3. Mala K. Maini, Antonio Bertoletti
      Pages 313-327
  11. Cytokines as Therapeutic Agents in Infectious Diseases

    1. Front Matter
      Pages 329-329
    2. Steven M. Holland, John I. Gallin
      Pages 331-344
    3. Guido Poli, Claudio Fortis, Adriano Lazzarin, Giuseppe Tambussi
      Pages 345-359
    4. Kai Hübel, David C. Dale, Richard K. Root, W. Conrad Liles
      Pages 361-378
  12. Anticytokine-Based Therapy in Treatment of Infectious Diseases

    1. Front Matter
      Pages 379-379
    2. Pierre-Yves Bochud, Michel P. Glauser, Thierry Calandra
      Pages 381-407
  13. Back Matter
    Pages 425-436

About this book


Recent years have witnessed rapid growth in new information on the crucial role played by cytokines and chemokines in human disease, as well as on the exciting possibilities they offer for developing novel therapies and for optimizing vaccine performance. In the Cytokines and Chemokines in Infectious Diseases Handbook, international leaders in the field comprehensively review what is known about the responses of cytokines and chemokines to a variety of human infectious diseases, including gram-negative and gram-positive infections, listeriosis, mycobacterial infections, lyme arthritis, pneumonia, fungal infections, HIV, leishmaniasis, and sepsis. The authors demonstrate the different cytokine and chemokine production profiles in response to a wide range of pathogens and the importance of host genetic factors in determining the type and magnitude of responses to a given micro-organism. They also critically evaluate the use of cytokines and anticytokines in the treatment of infectious diseases and show how knowledge of cytokine pleiotropic effects, redundancy, and the complexity of the cytokine network has led to better design and better outcomes in cytokine-based therapies for specific infections. The book also offers important information for those working in biodefense research through its illustration of the role of cytokines and chemokines in modulating host-pathogen interactions and vaccine responses.
Comprehensive and cutting-edge, the Cytokines and Chemokines in Infectious Diseases Handbook summarizes all the new scientific and clinical discoveries essential to understanding the importance of cytokines and chemokines in human infectious diseases, and demonstrates how best to utilize their unique properties in the design and development of effective new therapeutic agents.


HIV Hepatitis Lepra Parasitic Infections bacteria bacterial infection bacterial infections fungal infection gram-positive infection infection infections infectious infectious disease infectious diseases viral infection

Editors and affiliations

  • Malak Kotb
    • 1
  • Thierry Calandra
    • 2
  1. 1.Departments of Surgery and Molecular Sciences, VA Medical CenterUniversity of TennesseeMemphisUSA
  2. 2.Division of Infectious Diseases, Department of Internal MedicineCentre Hospital Universitaire VaudoisLausanneSwitzerland

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