© 2002

Microbial DNA and Host Immunity

  • Eyal Raz

Table of contents

  1. Front Matter
    Pages i-xvii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Eyal Raz
      Pages 3-8
    3. Saburo Yamamoto, Toshiko Yamamoto, Tohru Tokunaga
      Pages 9-14
  3. Receptors and Signaling

    1. Front Matter
      Pages 15-15
    2. Hiroaki Hemmi, Shizuo Akira
      Pages 39-47
    3. Wen-Ming Chu, Xing Gong, Tony Yoon
      Pages 49-61
    4. Katryn J. Stacey, David P. Sester, Shalin Naik, Tara L. Roberts, Matthew J. Sweet, David A. Hume
      Pages 63-77
  4. Cell Activation

    1. Front Matter
      Pages 79-79
    2. Saburo Yamamoto, Toshiko Yamamoto, Tetsuro Kataoka, Sumiko Iho, Tohru Tokunaga
      Pages 81-89
    3. David Askew, Rose S. Chu, Clifford V. Harding
      Pages 91-101
    4. Ae-Kyung Yi, Arthur M. Krieg
      Pages 103-127
    5. Hearn Jay Cho, Sandip Datta, Eyal Raz
      Pages 137-149
  5. Vaccination Strategies

    1. Front Matter
      Pages 151-151
    2. Maripat Corr, Chih Min Tang
      Pages 153-162
    3. Hiroko Kobayashi, Elena Martin-Orozco, Kenji Takabayashi, Anthony A. Horner
      Pages 163-174
    4. Kenji Takabayashi, Helen Tighe, Lucinda Beck, Hans L. Spiegelberg
      Pages 175-188

About this book


The immunostimulatory prospects of bacterial DNA have attracted the interest and attention of scientists and physicians and become a major focus in immunobiology and biomedicine. These activities are the product of immunostimulatory DNA sequences (ISS, also known as GpG motifs), which are rare in the mammalian genome. ISS were shown to enhance immunological responses and were used to confer protection to a wide variety of tumors, allergic inflammation, and infections. In Microbial DNA and Host Immunity, leading researchers review the activation of the mammalian immune system by bacterial DNA and consider the applications of ISS in clinical medicine. The authors survey the latest findings concerning the receptor-recognition and signaling pathways triggered by ISS, the process of cell activation, and potential vaccination strategies using ISS. Specific pharmaceutical applications discussed include infectious disease (Hepatitis B, HIV, and mycobacterial infections), allergy (asthma and conjunctivitis), cancer (lymphoma), and inflammation and autoimmunity (arthritis and colitis).
Up-to-date and informative, Microbial DNA and Host Immunity illuminates the immunobiology of bacterial DNA and its promise of powerful new vaccines to provide protective immunity against infections, tumors, and chronic disease.


Antigen Asthma DNA HIV Nucleotide infections infectious disease

Editors and affiliations

  • Eyal Raz
    • 1
  1. 1.University of California, San DiegoLa JollaUSA

Bibliographic information

  • Book Title Microbial DNA and Host Immunity
  • Editors Eyal Raz
  • DOI
  • Copyright Information Humana Press 2002
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-1-58829-022-9
  • Softcover ISBN 978-1-4684-9728-1
  • eBook ISBN 978-1-59259-305-7
  • Edition Number 1
  • Number of Pages XVII, 408
  • Number of Illustrations 95 b/w illustrations, 0 illustrations in colour
  • Topics Biochemistry, general
  • Buy this book on publisher's site
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"I am delighted, therefore to have found this book, which thoroughly reviews the field by contributions from most of the key names associated with the subject. For those not yet initiated into the tell-tale nature of ISS-DNA presented by non-self, the excellent introductory chapter by Eyal Raz(Editor) will reveal all you need to know to read the rest of the book. It summarizes the role of Toll Receptors(TLR) as sensors of infection by recognition of conserved molecular patterns in pathogenic bacteria (PAMPS), a subject very topical these days but riddled with a lot of new reference terms for the poor immunologist to contend with. This new book highlights the fact that even the ubiquitous DNA molecule has been the subject of critical censorship during evolution and has allowed the mammalian innate immune response to use subtle differences between prokaryotic and eukaryotic DNA to inform of bacterial invasion...recommended as an excellent library acquisition, if not a departmental one." -- Immunology News

"This is a worthwhile endeavor and the book is of value. Investigators interested in the overall utility of these DNA sequences will find useful material..." -Doody's Health Sciences Book Review Journal