© 2003

Neural Stem Cells for Brain and Spinal Cord Repair

  • Tanja Zigova
  • Evan Y. Snyder
  • Paul R. Sanberg

Part of the Contemporary Neuroscience book series (CNEURO)

Table of contents

  1. Front Matter
    Pages i-xix
  2. Stem Cells for and from the CNS

    1. Front Matter
      Pages 1-1
    2. Melissa K. Carpenter, Mark Mattson, Mahendra S. Rao
      Pages 3-44
    3. Angela Gritti, Angelo Vescovi, Rossella Galli
      Pages 45-68
    4. Martha Windrem, Neeta Roy, Marta Nunes, Steven A. Goldman
      Pages 69-88
    5. Eiji Nakagawa, Kozo Hatori, Atsushi Nagai, Hyun B. Choi, Myung A. Lee, Jung H. Bang et al.
      Pages 89-106
    6. Shijie Song, Paul Sanberg, Juan Sanchez-Ramos
      Pages 107-131
  3. In Vitro and/or In Vivo Manipulations of Stem/Progenitor Cells for the CNS

    1. Front Matter
      Pages 133-133
    2. Dennis A. Steindler, Bjorn Scheffler, Eric D. Laywell, Oleg N. Suslov, Tong Zheng, Thomas Reiniger et al.
      Pages 183-201
    3. Sanjay S. Magavi, Jeffrey D. Macklis
      Pages 229-267
    4. Jasodhara Ray, Daniel A. Peterson
      Pages 269-286
  4. Stem/Progenitor Cells in Representative Therapeutic Paradigms for the CNS

    1. Front Matter
      Pages 287-287
    2. Kook In Park, James J. Palacino, Roseanne Taylor, Karen S. Aboody, Barbara A. Tate, Vaclav Ourednik et al.
      Pages 289-332
    3. Yang D. Teng, Mary Katherine White, Erin Lavik, Shaoxiang Liu, Mahesh Lachyankar, Kook In Park et al.
      Pages 333-345
    4. Paul Lu, Evan Y. Snyder, Mark H. Tuszynski
      Pages 347-365
    5. Martin Marsala, Osamu Kakinohana, Tony L. Yaksh, Joho Tokumine
      Pages 367-393
    6. S. Ausim Azizi, Emily J. Schwarz, Darwin Prockop, Guillermo Alexander, Katherine A. Mortati, Barbara Krynska
      Pages 395-409
    7. Cesario V. Borlongan, Paul R. Sanberg
      Pages 411-429

About this book


Although neural stem cells (NSCs) have been successfully used in animal models of various neurodegenerative diseases and of brain and spinal cord injuries, their use in studies of nervous system dysfunction is still in its infancy. In Neural Stem Cells for Brain and Spinal Cord Repair, active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors (either produced intrinsically by the cells or induced to do so following genetic engineering) that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.
Comprehensive and up-to-date, Neural Stem Cells for Brain and Spinal Cord Repair provides the first systematic overview of the biological properties and functional characteristics of NSCs, as well as outlining of several possible areas of medicine and therapy where these cells may soon prove extremely helpful.


Nervous System Vivo cell division clinical application gene transfer neurons

Editors and affiliations

  • Tanja Zigova
    • 1
  • Evan Y. Snyder
    • 2
  • Paul R. Sanberg
    • 3
  1. 1.Center for Aging and Brain Repair, Departments of Neurosurgery, Anatomy and PharmacologyUniversity of South Florida College of MedicineTampaUSA
  2. 2.Department of Neurology, Harvard Medical School, Harvard Institutes of Medicine & Beth Israel-Deaconess Medical Center, Division of Newborn MedicineChildren’s Hospital-BostonBostonUSA
  3. 3.Center for Aging and Brain Repair, Departments of Neurosurgery, Neurology, Psychiatry and PharmacologyUniversity of South Florida College of MedicineTampaUSA

Bibliographic information

  • Book Title Neural Stem Cells for Brain and Spinal Cord Repair
  • Editors Tanja Zigova
  • Series Title Contemporary Neuroscience
  • DOI
  • Copyright Information Humana Press 2003
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-1-58829-003-8
  • Softcover ISBN 978-1-61737-298-8
  • eBook ISBN 978-1-59259-298-2
  • Edition Number 1
  • Number of Pages XIX, 434
  • Number of Illustrations 1 b/w illustrations, 53 illustrations in colour
  • Topics Neurosciences
  • Buy this book on publisher's site
Industry Sectors
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"The purpose is to address research protocols and possible future applications of neural stem cells in clinical practice. The author has met the objectives. . .Starting from the basic aspects of cell culturing, this book emphasizes the different available research protocols that are currently being used for possible management of neurological degenerative diseases. In addition, molecular mechanisms of interaction are always explained whenever necessary. This book is a perfect purchase for neurologists and neuroscientists. Neurosurgeons with a basic science interest would also find this a useful acquisition."-Doody's Health Sciences Book Review Journal