© 2002

Handbook of Copper Pharmacology and Toxicology

  • Edward J. Massaro

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Copper in Mammals

    1. Front Matter
      Pages 1-1
  3. Copper Proteins

    1. Front Matter
      Pages 33-33
    2. Svetlana Lutsenko, Ruslan Tsivkovskii, Matthew J. Cooper, Brian C. Macarthur, Hans-Peter Bächinger
      Pages 35-51
    3. Francesca De Rienzo, R. Razif Gabdoulline, Rebecca C. Wade, M. Cristina Menziani
      Pages 53-80
    4. Mattia Falconi, Alessandro Desideri
      Pages 81-101
    5. Lesley R. Brown, David A. Harris
      Pages 103-113
    6. David R. Brown
      Pages 115-129
    7. Shinya Yoshikawa
      Pages 131-152
    8. Daniel J. Kosman
      Pages 153-175
    9. Paul A. Cobine, Christopher E. Jones, Wasantha A. Wickramasinghe, Marc Solioz, Charles T. Dameron
      Pages 177-186
  4. Copper Transport

    1. Front Matter
      Pages 187-187
    2. Lisbeth Birk Møller, Nina Horn
      Pages 189-199
    3. Jimo Borjigin, Xing Sun, Michael M. Wang
      Pages 201-207
    4. Kunihiko Terada, Toshihiro Sugiyama
      Pages 227-234
  5. Molecular Pathogenesis of Diseases of Copper Metabolism

    1. Front Matter
      Pages 247-247
    2. Julian F. B. Mercer, David Kramer, James Camakaris
      Pages 249-276

About this book


Although copper is an essential trace element necessary for the survival of organisms ranging from bacteria to mammals, it is also highly toxic and must be absorbed by the body in precisely orchestrated biological processes. In Handbook of Copper Pharmacology and Toxicology, Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general, and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases-Menkes and Wilson's diseases and occipital horn syndrome-as well as the role of copper in Parkinson's disease, prion disease, familial amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The elucidation of the precise mechanisms of copper trafficking, metabolism, and homeostasis will be of considerable importance in understanding the pathophysiology and treatment of such diseases.
Comprehensive and timely, the Handbook of Copper Pharmacology and Toxicology authoritatively provides researchers with all the up-to-date information needed to work productively in copper biology today.


Alzheimer aquatic organisms biochemistry cancer metabolism research toxicity toxicology

Editors and affiliations

  • Edward J. Massaro
    • 1
  1. 1.The National Health and Environmental Effects Research LaboratoryResearch Triangle ParkUSA

Bibliographic information

  • Book Title Handbook of Copper Pharmacology and Toxicology
  • Editors Edward J. Massaro
  • DOI
  • Copyright Information Humana Press 2002
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-943-8
  • Softcover ISBN 978-1-61737-266-7
  • eBook ISBN 978-1-59259-288-3
  • Edition Number 1
  • Number of Pages XVI, 608
  • Number of Illustrations 114 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Pharmacology & Toxicology
Consumer Packaged Goods


"...biochemical and molecular researchers from around the globe have produced 35 chapters documenting the present state of knowledge in selected areas of copper pharmacology and toxicology. the state-of-the-art data provided will no doubt stimulate challenging research with this essential trace element required by organism ranging from bacteria to mammals." - Veterinary and Human Toxicology

"The book has excellent introductory chapters, and summarizes much recent research at the genetic and cellular levels." - Newsletter of the British Toxicological Society

"Dr. Massaro must be congratulated for editing this comprehensive book on copper. There are so many outstanding chapters in this compendium that highlighting any one of them should not detract from the others...this book is a treasure trove of references. The price of the book, though modest for this compendium would be justified for the Preface and the first chapter alone. This book is highly recommended. At the present time it has no equal." -International Journal of Toxicology