Handbook of Copper Pharmacology and Toxicology

  • Edward J. Massaro

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Copper in Mammals

    1. Front Matter
      Pages 1-1
  3. Copper Proteins

    1. Front Matter
      Pages 33-33
    2. Svetlana Lutsenko, Ruslan Tsivkovskii, Matthew J. Cooper, Brian C. Macarthur, Hans-Peter Bächinger
      Pages 35-51
    3. Francesca De Rienzo, R. Razif Gabdoulline, Rebecca C. Wade, M. Cristina Menziani
      Pages 53-80
    4. Mattia Falconi, Alessandro Desideri
      Pages 81-101
    5. Lesley R. Brown, David A. Harris
      Pages 103-113
    6. David R. Brown
      Pages 115-129
    7. Shinya Yoshikawa
      Pages 131-152
    8. Daniel J. Kosman
      Pages 153-175
    9. Paul A. Cobine, Christopher E. Jones, Wasantha A. Wickramasinghe, Marc Solioz, Charles T. Dameron
      Pages 177-186
  4. Copper Transport

    1. Front Matter
      Pages 187-187
    2. Lisbeth Birk Møller, Nina Horn
      Pages 189-199
    3. Jimo Borjigin, Xing Sun, Michael M. Wang
      Pages 201-207
    4. Kunihiko Terada, Toshihiro Sugiyama
      Pages 227-234
  5. Molecular Pathogenesis of Diseases of Copper Metabolism

    1. Front Matter
      Pages 247-247
    2. Julian F. B. Mercer, David Kramer, James Camakaris
      Pages 249-276
    3. Giuseppe Rotilio, Maria Rosa Ciriolo, Maria Teresa Carrì, Luisa Rossi
      Pages 277-296
    4. Edward D. Harris, Manchi C. M. Reddy, Sudeep Majumdar
      Pages 333-341
    5. Zeynep Tümer, Nina Horn, Lars Riff Jensen
      Pages 343-356
    6. Cisca Wijmenga
      Pages 369-382
  6. Copper Toxicity and Therapeutics

    1. Front Matter
      Pages 383-383
    2. Magdalena Araya, Mauricio González, Manuel Olivares, Ricardo Uauy
      Pages 385-396
    3. Simonetta Ferruzza, Yula Sambuy, Andrea Onetti-Muda, Fabio Nobili, Maria Laura Scarino
      Pages 397-416
    4. Aldo Viarengo, Bruno Burlando, Claudia Bolognesi
      Pages 417-431
    5. Dominik Klein, Josef Lichtmannegger, Karl H. Summer
      Pages 461-471
  7. Copper Metabolism and Homeostasis

    1. Front Matter
      Pages 473-473
    2. Zhiwu Zhu, Jose Heredia, Ryan Teves
      Pages 475-480
    3. Sharon La Fontaine, Jeanette Quinn, Sabeeha Merchant
      Pages 481-502
    4. Erik Vijgenboom, Bart Keijser
      Pages 503-525
    5. Reinhard Wimmer, Charles T. Dameron, Marc Solioz
      Pages 527-542
    6. Helena Mira, Vicente Sancenón, Lola Peñarrubia
      Pages 543-557
    7. J. Colin Murrell, Graham Stafford, Ian R. Mcdonald
      Pages 559-569
    8. Simon Labbé, Jude Beaudoin, Daniel R. Bellemare, Benoit Pelletier
      Pages 571-587
  8. Back Matter
    Pages 589-608

About this book


Although copper is an essential trace element necessary for the survival of organisms ranging from bacteria to mammals, it is also highly toxic and must be absorbed by the body in precisely orchestrated biological processes. In Handbook of Copper Pharmacology and Toxicology, Edward J. Massaro and a panel of leading biomedical researchers and clinical practitioners review, in-depth, the status of our current knowledge concerning the biochemistry of copper in general, and its role in health and disease in particular. Drawing on the wealth of new information emerging from the molecular biology revolution, these experts survey the most important research areas of copper pharmacology and toxicology, including copper proteins and transport, copper toxicity and therapeutics, and copper metabolism and homeostasis. They also discuss the molecular pathogenesis of copper in a variety of metabolic diseases-Menkes and Wilson's diseases and occipital horn syndrome-as well as the role of copper in Parkinson's disease, prion disease, familial amyotrophic lateral sclerosis (ALS), and Alzheimer's disease. The elucidation of the precise mechanisms of copper trafficking, metabolism, and homeostasis will be of considerable importance in understanding the pathophysiology and treatment of such diseases.
Comprehensive and timely, the Handbook of Copper Pharmacology and Toxicology authoritatively provides researchers with all the up-to-date information needed to work productively in copper biology today.


Alzheimer aquatic organisms biochemistry cancer metabolism research toxicity toxicology

Editors and affiliations

  • Edward J. Massaro
    • 1
  1. 1.The National Health and Environmental Effects Research LaboratoryResearch Triangle ParkUSA

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