Buprenorphine Therapy of Opiate Addiction

  • Pascal Kintz
  • Pierre Marquet

Part of the Forensic Science and Medicine book series (FSM)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Pierre Marquet
    Pages 1-11
  3. Michel Mallaret, Maurice Dematteis, Celine Villier, Claude Elisabeth Barjhoux, Chantal Gatignol
    Pages 51-67
  4. Marc Deveaux, Jean Vignau
    Pages 69-81
  5. Pascal Kintz
    Pages 109-117
  6. Pierre Marquet, Pierre Lavignasse, Jean-Michel Gaulier, Gérard Lachâtre
    Pages 125-135
  7. Claude Lejeune, Sandrine Aubisson, Laurence Simmat-Durand, Fabrice Cneude, Martine Piquet
    Pages 137-146
  8. Back Matter
    Pages 147-148

About this book


Buprenorphine, a semisynthetic opioid derivative, has been prescribed widely and uniquely in France as an alternative to methadone for the treatment of heroin-addicted patients during the last five years. In Buprenorphine Therapy of Opiate Addiction, participating physicians and toxicologists summarize and evaluate their experiences with this still uncommon drug, covering all aspects of its use, including the pharmacology, conditions of delivery, risks from use with other psychoactive drugs, toxicology and related deaths, as well as its testing in blood, urine, tissue, and hair. Special attention is given to comparing the long-term care of opiate-dependent patients using high-dose buprenorphine vs methadone, and to explaining the differences in treatment, administration, and delivery. The authors also describe how buprenorphine is currently prescribed and monitored in France and Australia, and review all the latest advances in analytical techniques for the determination of buprenorphine and its metabolites in biological fluids and tissues. Special coverage is given to the use of buprenorphine in the pregnant addict, the risks of buprenorphine overdosing and poisoning, and the effects of combining buprenorphine and naloxone.
Comprehensive and groundbreaking, Buprenorphine Therapy of Opiate Addiction covers all the key topics that both treatment personnel and forensic laboratory scientists in the addiction field need to appreciate the success of buprenorphine therapy, and to prepare for its implementation in their own countries.


Methadon pharmacodynamics pharmacokinetics pharmacology toxicology

Editors and affiliations

  • Pascal Kintz
    • 1
    • 2
  • Pierre Marquet
    • 3
    • 4
  1. 1.Institute of Legal MedicineStrasbourgFrance
  2. 2.Societé Française de Toxicologie AnalytiqueFrance
  3. 3.Department of Pharmacology and ToxicologyUniversity HospitalFrance
  4. 4.Faculty of MedicineLimoges UniversityLimogesFrance

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