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Combination Vaccines

Development, Clinical Research, and Approval

  • Ronald W. Ellis

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Emmanuel Vidor, Agnes Hoffenbach, Stanley Plotkin
    Pages 1-33
  3. Dennis M. Katkocin, Chia-Lung Hsieh
    Pages 51-93
  4. Peter R. Paradiso, Robert Kohberger
    Pages 95-106
  5. Bert E. Johansson
    Pages 133-153
  6. Kenneth R. Brown, Francis M. Ricci
    Pages 155-169
  7. Paul A. Offit, H. Fred Clark
    Pages 171-195
  8. Maurice R. Hilleman
    Pages 197-211
  9. John R. Vose
    Pages 213-231
  10. Lydia A. Falk, Karen Midthun, Loris D. McVittie, Karen L. Goldenthal
    Pages 233-248
  11. Kathryn M. Edwards, Michael D. Decker
    Pages 249-267
  12. Back Matter
    Pages 269-279

About this book

Introduction

A diverse team of leading experts comprehensively review the complex biology of a wide variety of vaccine combinations, as well as the technical, clinical, and regulatory aspects of their development. Topics covered range from the use of immunological correlates of efficacy, rather than efficacy per se, for the evaluation and licensure of vaccine combinations, to preserving a stable immunogenic mixture in appropriate containers according to accepted regulatory standards. Discussed in detail are the trivalent influenza vaccine, the pneumococcal polysaccharide vaccine, the MMR vaccine, the DTP vaccine and its combinations, and the quadrivalent rotavirus vaccine, all of which serve as models for the development of future combinations. Combination Vaccines: Development, Clinical Research, and Approval illuminates all the scientific, clinical, regulatory, and health care issues involved in the research, development, and human use of combination vaccines.






Keywords

clinical research diseases infectious disease research vaccine

Editors and affiliations

  • Ronald W. Ellis
    • 1
  1. 1.Vaccine DevelopmentBioChem Pharma, Inc.NorthboroughUSA

Bibliographic information

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