© 2000

Gene Engineering in Endocrinology

  • Margaret A. Shupnik

Part of the Contemporary Endocrinology book series (COE, volume 22)

Table of contents

  1. Front Matter
    Pages i-x
  2. Growth, Development, and Metabolism

    1. Front Matter
      Pages N1-N1
    2. Michael J. Quon, Simeon I. Taylor
      Pages 17-38
    3. Andrew P. Bradford, Arthur Gutierrez-Hartmann
      Pages 39-65
    4. Bryan R. Haugen, David F. Gordon, William M. Wood
      Pages 67-86
    5. Uma R. Chandran, Donald B. DeFranco
      Pages 87-97
    6. Jung-Hsin Hsu, Gregory A. Brent
      Pages 119-133
    7. Ronald N. Cohen, Fredric E. Wondisford
      Pages 135-151
    8. Mark W. Nachtigal, Debra Enyeart-VanHouten, Holly A. Ingraham
      Pages 153-166
  3. Reproductive System

About this book


Recent advances in genetic engineering and molecular biology have made it possible to disrupt specific genes in order to determine and better understand their function and clinical significance. In Gene Engineering in Endocrinology, Margaret Shupnik and a team of leading investigators review the most recent breakthroughs, emphasizing how studies of natural mutations and gene knockouts have illuminated endocrine processes. Using both animal and human model data, these authoritative researchers examine in depth the molecular basis of development, growth, and reproductive processes, the specific mutations that explain certain genetic syndromes, the hormonal regulation of gene expression (which affects the treatment of infertility and steroid-dependent cancers), and current research directions. When possible, molecular studies are compared with naturally occurring human and animal gene mutations to establish the difference between complete elimination of, or an altered, gene function.
Comprehensive and up-to-date, Gene Engineering in Endocrinology offers today's experimental and clinical endocrinologists, as well as reproductive biologists, a richly informative survey of what has already been accomplished with the genetic engineering of hormone processes and hormone-related genetic syndromes-research that promises powerful new experimental and therapeutic opportunities as this field continues it rapid development.


Gonadotropin glucocorticoid hormone receptors insulin nuclear receptors signaling pathways thyroid hormone

Editors and affiliations

  • Margaret A. Shupnik
    • 1
  1. 1.Division of Endocrinology, Department of Internal MedicineUniversity of Virginia Health Sciences CenterCharlottesvilleUSA

Bibliographic information

  • Book Title Gene Engineering in Endocrinology
  • Editors Margaret A. Shupnik
  • Series Title Contemporary Endocrinology
  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-718-2
  • Softcover ISBN 978-1-61737-147-9
  • eBook ISBN 978-1-59259-221-0
  • Edition Number 1
  • Number of Pages XII, 428
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Endocrinology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


"The editor should be congratulated on bringing together some of the most respected researchers in this area to write state-of-the-art papers in the area of molecular endocrinology. . . Graduate students and fellows interested in basic endocrinology would find this book a worthwhile investment with good diagrams and well-written summaries of some of the more confusing areas of this field. . .I love the book and will keep it handy when I sit down and decipher the new papers in molecular biology."-Doody's Health Science Book Review Journal