© 2000

Signaling Networks and Cell Cycle Control

The Molecular Basis of Cancer and Other Diseases

  • J. Silvio Gutkind

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Kenneth M. Yamada, Erik H. J. Danen
    Pages 1-25
  3. Paolo Fedi, Stuart A. Aaronson
    Pages 27-38
  4. Anita B. Roberts, Mark P. de Caestecker, Robert J. Lechleider
    Pages 39-51
  5. Grant D. Barish, Bart O. Williams
    Pages 53-82
  6. Shigetomo Fukuhara, Maria Julia Marinissen, Mario Chiariello, J. Silvio Gutkind
    Pages 83-98
  7. Joanne Sloan-Lancaster, Lawrence E. Samelson
    Pages 99-111
  8. Reuben P. Siraganian
    Pages 113-134
  9. Richard M. Siegel, David A. Martin, Felicita Hornung, Erastus C. Dudley, Lixin Zheng, Michael J. Lenardo
    Pages 135-152
  10. Kathleen Kelly, Yanfang Chu
    Pages 165-182
  11. Gary R. Fanger, Thomas K. Schlesinger, Gary L. Johnson
    Pages 183-211
  12. Geoffrey J. Clark, John P. O’Bryan, Channing J. Der
    Pages 213-230
  13. David A. Fruman, Lewis C. Cantley
    Pages 247-266
  14. Randal S. Tibbetts, Robert T. Abraham
    Pages 267-301
  15. Jean Y. J. Wang
    Pages 303-324
  16. Src
    Pamela L. Schwartzberg
    Pages 325-345
  17. Peter M. Blumberg, Peter Acs, Dipak K. Bhattacharyya, Patricia S. Lorenzo
    Pages 347-364
  18. Toren Finkel, Daniel M. Sullivan
    Pages 365-377

About this book


The recent dramatic expansion of our knowledge about how cell surface receptors transmit signals to the nucleus, together with the identification of key signaling and cell-cycle-regulating molecules, has provided a major opportunity to search for novel targets for therapeutic intervention in many diseases. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, leading scientists summarize this knowledge and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules.
Rich in cutting-edge insights and authoritative critical analysis, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.


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Editors and affiliations

  • J. Silvio Gutkind
    • 1
  1. 1.Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaUSA

Bibliographic information

  • Book Title Signaling Networks and Cell Cycle Control
  • Book Subtitle The Molecular Basis of Cancer and Other Diseases
  • Editors J. Silvio Gutkind
  • Series Title Cancer Drug Discovery and Development
  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-710-6
  • Softcover ISBN 978-1-4684-9695-6
  • eBook ISBN 978-1-59259-218-0
  • Edition Number 1
  • Number of Pages XIV, 578
  • Number of Illustrations 97 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacy
  • Buy this book on publisher's site
Industry Sectors
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"Each chapter contains a well-referenced, clearly illustrated and up-to-date summary of the state of affairs including a discussion of the areas that are still open for further work. The volume provides a good read for both workers actively engaged in drug research as well as those working in the more fundamental areas of signaling and the cell cycle." - Cell Biology and Function

"...the range of topics included in this book is impressive....This volume works well on many levels. For graduate students struggling to assimilate the large body of signaling literature, the first half of the book offers what amounts to a comprehensive review of the most basic aspects of signal transduction. For experts, these same chapters serve as a point of departure for the second half, which deals with the emerging body of literature on how one can manipulate signaling pathways in the treatment of disease. It is the combination of basic and applied aspects of signal transduction that makes this book unique....the editor has done a remarkable job in selecting and assembling reviews from experts in signal transduction, and for presenting such a lucid discussion of this complex field." - Quarterly Review of Biology

"Each chapter is well referenced and stands alone as a comprehensive review in a specific area of signaling networks and cell-cycle control. In many cases the authors have highlighted several areas that are still open for further investigation, and have attempted to define the most likely molecular targets for pharmacological intervention...I would recommend this as a must have reference book, aimed mainly at an expert audience, which any good academic or biotechnological company library should have." - Cell Biology International