Signaling Networks and Cell Cycle Control

The Molecular Basis of Cancer and Other Diseases

  • J. Silvio Gutkind

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Kenneth M. Yamada, Erik H. J. Danen
    Pages 1-25
  3. Paolo Fedi, Stuart A. Aaronson
    Pages 27-38
  4. Anita B. Roberts, Mark P. de Caestecker, Robert J. Lechleider
    Pages 39-51
  5. Grant D. Barish, Bart O. Williams
    Pages 53-82
  6. Shigetomo Fukuhara, Maria Julia Marinissen, Mario Chiariello, J. Silvio Gutkind
    Pages 83-98
  7. Joanne Sloan-Lancaster, Lawrence E. Samelson
    Pages 99-111
  8. Reuben P. Siraganian
    Pages 113-134
  9. Richard M. Siegel, David A. Martin, Felicita Hornung, Erastus C. Dudley, Lixin Zheng, Michael J. Lenardo
    Pages 135-152
  10. Kathleen Kelly, Yanfang Chu
    Pages 165-182
  11. Gary R. Fanger, Thomas K. Schlesinger, Gary L. Johnson
    Pages 183-211
  12. Geoffrey J. Clark, John P. O’Bryan, Channing J. Der
    Pages 213-230
  13. David A. Fruman, Lewis C. Cantley
    Pages 247-266
  14. Randal S. Tibbetts, Robert T. Abraham
    Pages 267-301
  15. Jean Y. J. Wang
    Pages 303-324
  16. Src
    Pamela L. Schwartzberg
    Pages 325-345
  17. Peter M. Blumberg, Peter Acs, Dipak K. Bhattacharyya, Patricia S. Lorenzo
    Pages 347-364
  18. Toren Finkel, Daniel M. Sullivan
    Pages 365-377
  19. Sarah Spiegel, Sheldon Milstien
    Pages 379-392
  20. Andrew C. Larner, Andrew Keightley
    Pages 393-409
  21. Kevin M. Ryan, Karen H. Vousden
    Pages 411-427
  22. Frank Mercurio, Anthony M. Manning
    Pages 429-438
  23. David T. Dudley, Alan R. Saltiel
    Pages 467-481
  24. Peter R. Young
    Pages 483-500
  25. Adrienne D. Cox, Channing J. Der
    Pages 501-518
  26. Esther H. Chang, Liang Xu, Kathleen F. Pirollo
    Pages 519-536
  27. Edward A. Sausville, Adrian M. Senderowicz
    Pages 557-567
  28. Back Matter
    Pages 568-578

About this book


The recent dramatic expansion of our knowledge about how cell surface receptors transmit signals to the nucleus, together with the identification of key signaling and cell-cycle-regulating molecules, has provided a major opportunity to search for novel targets for therapeutic intervention in many diseases. In Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases, leading scientists summarize this knowledge and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules.
Rich in cutting-edge insights and authoritative critical analysis, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.


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Editors and affiliations

  • J. Silvio Gutkind
    • 1
  1. 1.Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaUSA

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