© 2002

Handbook of Neurotoxicology

Volume II

  • Edward J. Massaro

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Developmental Neurotoxicology

    1. Front Matter
      Pages 1-1
    2. Judith W. Henck
      Pages 3-56
    3. Gregg D. Cappon, Donald G. Stump
      Pages 81-109
  3. Drugs of Abuse

    1. Front Matter
      Pages 129-129
    2. Kenneth R. Alper, Leslie S. Prichep, E. Roy John, Sharon C. Kowalik, Mitchell S. Rosenthal
      Pages 131-154
    3. Eliot L. Gardner
      Pages 155-173
    4. Katherine R. Bonson, Matthew Baggott
      Pages 223-257
    5. Jean Lud Cadet, Christie Brannock
      Pages 259-268
    6. James P. O’Callaghan, Diane B. Miller
      Pages 269-301
    7. Patricia A. Broderick
      Pages 323-367
  4. Imaging

    1. Front Matter
      Pages 369-369
    2. David J. Lyons, Cory S. Freedland, Linda J. Porrino
      Pages 371-395
    3. Linda J. Porrino, David J. Lyons, Sharon R. Letchworth, Cory S. Freedland, Michael A. Nader
      Pages 413-435

About this book


Neurotoxins-whether natural products that can provide valuable therapeutic agents and research reagents or human-generated pollutants-have recently attracted great scientific interest. In the Handbook of Neurotoxicology, Volumes I and II, many leading researchers and clinicians-all acknowledged experts-review in depth the status of research in key areas of current neurotoxicologic interest and examine the latest methodologies for in vivo assessment of a wide spectrum of agents exhibiting neurotoxicologic properties. This second volume of the Handbook focuses on the biologic effects of human-made toxins on the developing organism, and of drugs of abuse. Here are discussed the interpretation of neurotoxicity data, the art of risk assessment, and the manifestation of CNS insult during development. The drugs of abuse surveyed include cocaine, marijuana, the cannabinoids, and amphetamines. Also provided are state-of-the-art methods for the evaluation of neurotoxicant effects by both imaging and neurobehavioral assessment. Volume I concentrates on the biological effects of both human-made neurotoxins (pesticides, mercury, lead, zinc, and polytypic by-products of combustion and manufacture) and those of natural origin (microbial and animal toxins).
Up-to-date and timely, the Handbook of Neurotoxicology, Volumes I and II, not only affords today's biomedical and clinical investigators a full panoply of knowledge in all the critical areas of current neurotoxicologic interest, but also illuminates the latest methodologies for assessing the effects of a broad spectrum of significant neurotoxicological agents.


Cannabinoid Ethanol animal toxin cocaine developmental neurotoxicology drugs of abuse lead marijuana neural degeneration neurobehavioral assessment neuroimaging neurotoxicology pesticide psychosis zinc

Editors and affiliations

  • Edward J. Massaro
    • 1
  1. 1.The National Health and Environmental Effects Research LaboratoryDurhamUSA

Bibliographic information

  • Book Title Handbook of Neurotoxicology
  • Book Subtitle Volume II
  • Editors Edward J. Massaro
  • DOI
  • Copyright Information Humana Press 2002
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-796-0
  • Softcover ISBN 978-1-61737-194-3
  • eBook ISBN 978-1-59259-165-7
  • Edition Number 1
  • Number of Pages XVI, 594
  • Number of Illustrations 21 b/w illustrations, 11 illustrations in colour
  • Topics Pharmacology/Toxicology
  • Buy this book on publisher's site
Industry Sectors
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"This book presents a set of 21 well-chosen, up to date, reviews of a range of important topics of direct interest to neurotoxicologists in particular, but also to anyone with an interest in animal models of nervous system disease or in pathogenesis. As the title of this proposed series of volumes implies, the editors intend to cover the whole of the field, by adding further volumes in response to reader's requests - so no excuses for gaps!...The coverage is wide...It would be a pity if the emphasis on drugs of abuse put non-specialists off buying the book, because the strong mechanistic treatment of many of the chapters emphasizes the useful parallels with other, less "stimulating", neurotoxic agents. This is certainly not a book just about overdose pharmacology. " - Newsletter of the British Toxicological Society

"The Handbook of Neurotoxicology is an essential addition to the library of any serious researcher in any field of neurotoxicology and should be available in all university libraries where chemistry, biochemistry, or medical or life sciences are studied." - Journal of Natural Products

"Both volumes are laid out attractively...and contain much valuable information on the pharmacological aspects of neurotoxicology, as well as state-of-the-art methodology." Le Journal Canadien Des Sciences Neurologies