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© 2002

Selective Estrogen Receptor Modulators

Research and Clinical Applications

  • Andrea Manni
  • Michael F. Verderame
Book

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages i-x
  2. Molecular Mechanisms of Estrogen Receptor Function

    1. Front Matter
      Pages 1-1
    2. Stefan Nilsson, Jan-Åke Gustafsson
      Pages 3-18
    3. Paul Webb
      Pages 57-76
  3. Tissue-Specific Effects of Estrogens and SERMs

    1. Front Matter
      Pages 97-97
    2. Munish K. Goyal, Suzanne Oparil
      Pages 99-119
    3. Bruce S. McEwen, Phyllis M. Wise, Stanley Birge
      Pages 121-144
  4. Preclinical Studies

    1. Front Matter
      Pages 145-145
    2. Csaba Gajdos, James Zapf, V. Craig Jordan
      Pages 147-165
    3. Fernand Labrie, Claude Labrie, Alain Bélanger, Jacques Simard
      Pages 167-187
  5. Organ Specific Effects of Estrogens and SERMs

    1. Front Matter
      Pages 189-189
    2. Nanette F. Santoro, Peter Kovacs
      Pages 191-206
    3. Jacques E. Rossouw
      Pages 207-222
    4. Michael Kleerekoper, Ashish Verma
      Pages 237-243
    5. Aurelie Fontana, Pierre D. Delmas
      Pages 245-254
    6. Alan J. Lerner
      Pages 255-264

About this book

Introduction

Hormone replacement therapy with selective estrogen receptor modulators (SERMs) promises the highly desirable benefits of estrogen and progesterone replacement therapy, while avoiding their associated risks of breast and uterine cancer, gallbladder disease, and weight gain. In Selective Estrogen Receptor Modulators: Research and Clinical Applications, leading experimental and clinical researchers from a wide range of disciplines present a wealth of fresh scientific information on the biochemistry, molecular biology, pharmacology, and clinical activity of SERMs. The basic science chapters of the book focus-with an eye to the development of the ideal SERM-on the complex mechanisms of estrogen action, including ligand-dependent conformational changes in alpha and beta, and the recruitment of coactivators and corepressors which modulate the estrogen receptor transcriptional activity and contribute to its crosstalk with growth factor signaling. The clinical presentations review the data accumulated on currently available SERMs, primarily tamoxifen and raloxifene, in cancer treatment and prevention, as well as their effects on the reproductive, vascular, skeletal, and central nervous systems. A novel approach to menopause-related health issues is also provided for women with and without a previous diagnosis of localized breast cancer.
Multidisciplinary and state-of-the-art, Selective Estrogen Receptor Modulators: Research and Clinical Applications provides experimentalists and clinicians alike a comprehensive overview of the basic mechanisms of estrogen and SERMs action, as well as evidence-based guidelines for their clinical use in postmenopausal women.

Keywords

estrogen action estrogen receptor growth growth factor hormone

Editors and affiliations

  • Andrea Manni
    • 1
  • Michael F. Verderame
    • 1
  1. 1.Division of Endocrinology, Diabetes, and Metabolism, Milton S. Hershey Medical CenterPennsylvania State University College of MedicineHersheyUSA

Bibliographic information

  • Book Title Selective Estrogen Receptor Modulators
  • Book Subtitle Research and Clinical Applications
  • Editors Andrea Manni
    Michael Verderame
  • Series Title Contemporary Endocrinology
  • DOI https://doi.org/10.1007/978-1-59259-157-2
  • Copyright Information Humana Press 2002
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-912-4
  • Softcover ISBN 978-1-4684-9665-9
  • eBook ISBN 978-1-59259-157-2
  • Edition Number 1
  • Number of Pages X, 374
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Endocrinology
  • Buy this book on publisher's site
Industry Sectors
Biotechnology
Health & Hospitals
Internal Medicine & Dermatology
Pharma

Reviews

"...this book is densely packed with data will be valuable for investigators in the field as well as those new to this area. There are many details of interest to the molecular endocrinologist. The clinical information is also intriguing for the clinician who needs to know how to apply the SERMs in the management of postmenopausal problems." - Oncology

"Selective Estrogen Receptor Modulators: Research and Clinical Application is an indispensable resource for evaluating the use of SERM potential alternatives to estrogens. The book synthesizes the current understanding of SERM at the levels of molecular mechanisms and clinical applications and provides a precise and balanced view of ongoing research and future developments. Clearly written and supported by informative illustrations, it is aimed at a specialized audience and should be particularly useful to researchers and clinicians eager to advance their knowledge of these so-called 'designer estrogens'. Selective Estrogen Receptor Modulators is an excellent collection of timely reviews. Its major strength is combining basic and clinical studies in a thorough account of current knowledge about estrogens and SERM." -Trends in Endocrinology and Metabolism