© 2002

Cytokines and Autoimmune Diseases

  • Vijay K. Kuchroo
  • Nora Sarvetnick
  • David A. Hafler
  • Lindsay B. Nicholson

Table of contents

  1. Front Matter
    Pages i-xi
  2. Cytokines: Induction and Regulation

    1. Front Matter
      Pages 1-1
    2. Jyothi Rengarajan, Laurie H. Glimcher
      Pages 3-23
    3. Janet E. Buhlmann, Arlene H. Sharpe
      Pages 79-118
    4. Mark Exley, S. Brian Wilson
      Pages 119-141
    5. Luk Van Parijs, Abul K. Abbas
      Pages 143-156
  3. Cytokines: Role in Specific Autoimmune Diseases

    1. Front Matter
      Pages 193-193
    2. Benjamin M. Segal, Ethan M. Shevach
      Pages 195-225
    3. Estelle Bettelli, Lindsay B. Nicholson
      Pages 247-271
    4. Sally C. Kent, Vissia Viglietta, David A. Hafler
      Pages 295-316
    5. Marie Wahren-Herlenius, Helena Erlandsson Harris, Per Larsson, Lars Klareskog
      Pages 317-354
    6. Amy E. Wandstrat, Edward K. Wakeland
      Pages 355-371
    7. Premkumar Christadoss, Elzbieta Goluszko
      Pages 373-385
  4. Cytokines and Autoimmunity: A Synthesis

    1. Front Matter
      Pages 387-387
    2. Vijay K. Kuchroo, Lindsay B. Nicholson
      Pages 389-406

About this book


Although the role of cytokines and chemokines in the induction and regulation of autoimmunity has a vast current literature, there is as yet no clear consensus about the details of this complex process. In Cytokines and Autoimmune Diseases, leading researchers synthesize the available information to help develop an intimate understanding of how cytokines and chemokines are involved in the pathogenesis of autoimmune diseases. The many chapters offer critical reviews of the basic mechanisms controlling cytokine induction and regulation, as well as the resulting production of proinflammatory and anti-inflammatory cytokines, the former of which induces organ-specific autoimmune diseases. From the vantage of these insights, they address the role of cytokines in a wide variety of autoimmune disease, uvetis, encephalomyelitis, multiple sclerosis, human type 1 diabetes, rheumatoid arthritis, SLE, and myasthenia gravis.
Authoritative and state-of-the-art, Cytokines and Autoimmune Diseases comprehensively integrates the diffuse literature of this dramatically advancing field, and highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease.


Chemokine T cell autoimmune disease autoimmunity cytokine diseases pathogenesis resistance

Editors and affiliations

  • Vijay K. Kuchroo
    • 1
  • Nora Sarvetnick
    • 2
  • David A. Hafler
    • 1
  • Lindsay B. Nicholson
    • 1
  1. 1.Center for Neurologic Diseases, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA
  2. 2.Department of ImmunologyScripps Research InstituteLa JollaUSA

Bibliographic information

  • Book Title Cytokines and Autoimmune Diseases
  • Editors Vijay K. Kuchroo
    Nora Sarvetnick
    David A. Hafler
    Lindsay B. Nicholson
  • DOI
  • Copyright Information Springer Science+Business Media New York 2002
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-856-1
  • Softcover ISBN 978-1-61737-225-4
  • eBook ISBN 978-1-59259-129-9
  • Edition Number 1
  • Number of Pages XI, 422
  • Number of Illustrations 23 b/w illustrations, 0 illustrations in colour
  • Topics Immunology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals


"Authoritative and state-of-the-art, Cytokines and Autoimmune Disease highlights the enormous therapeutic potential of cytokine modulation in the treatment of autoimmune disease." -Immunology News