The Molecular Basis of Human Cancer

  • William B. Coleman
  • Gregory J. Tsongalis

Table of contents

  1. Front Matter
    Pages i-xii
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. William B. Coleman, Gregory J. Tsongalis
      Pages 3-22
  3. Essential Concepts in Molecular Biology

    1. Front Matter
      Pages 23-23
    2. Sharon Collins Presnell
      Pages 25-42
  4. Molecular Themes in Oncogenesis

    1. Front Matter
      Pages 43-43
    2. John J. Reinartz
      Pages 45-64
    3. James N. Welch, Susan A. Chrysogelos
      Pages 65-79
    4. Kara N. Smolinski, Stephen J. Meltzer
      Pages 81-111
  5. Mechanisms of Mutation

    1. Front Matter
      Pages 113-113
    2. William B. Coleman, Gregory J. Tsongalis
      Pages 115-142
    3. Takashi Shimamoto, Kazuma Ohyashiki
      Pages 143-158
    4. Bruce M. Boman, Lael Melchert, Jeremy Z. Fields
      Pages 159-185
  6. Etiology of Human Cancers

    1. Front Matter
      Pages 187-187
    2. Lorenzo Tomatis, James Huff
      Pages 189-201
    3. Edward L. Loechler, Bryan Henry, Kwang-Young Seo
      Pages 203-222
    4. Cynthia R. Timblin, Yvonne Janssen-Heininger, Brooke T. Mossman
      Pages 223-232
    5. Felix Hoppe-Seyler, Karin Butz
      Pages 233-247
  7. Human Tumor Systems

    1. Front Matter
      Pages 249-249
    2. J. Milburn Jessup, Gary Gallick, Bo Liu
      Pages 251-268
    3. April Charpentier, C. Marcelo Aldaz
      Pages 347-363
    4. Allen C. Gao, John T. Isaacs
      Pages 365-378
    5. Kwun M. Fong, Yoshitaka Sekido, John D. Minna
      Pages 379-405
    6. Caterina Missero, Mariarosaria D’Errico, Gian Paolo Dotto, Eugenia Dogliotti
      Pages 407-425
    7. Arnold B. Gelb, L. Jeffrey Medeiros
      Pages 427-460
    8. Gregory J. Tsongalis, William N. Rezuke
      Pages 461-474
  8. Future Directions

    1. Front Matter
      Pages 475-475
    2. Katherine Schneider, Kristen Shannon, Anu Chittenden, Elaine Hiller, Stephanie Kieffer
      Pages 477-495
    3. Elizabeth M. Petty, Beverly M. Yashar
      Pages 497-520
    4. John K. Buolamwini
      Pages 521-540
    5. Jesús Gómez-Navarro, Guadalupe Bilbao, David T. Curiel
      Pages 541-565
  9. Back Matter
    Pages 567-588

About this book


Molecular biology holds great promise for the development of new strategies for cancer prevention and treatment. In The Molecular Basis of Human Cancer, internationally renowned basic and clinical scientists provide an account of our best current understanding of the genetics of cancer. These authoritative contributors describe in detail each of the known molecular mechanisms governing neoplastic transformation in the breast, prostate, lung, liver, colon, skin, and in the leukemias and lymphomas. Their discussion illuminates both recent developments and established concepts in epidemiology, molecular techniques, oncogenesis, and mutation mechanisms, as well as the chemical, viral, and physical mechanisms of cancer induction. They also consider the future directions of research, including discussions of the exploitation of molecular targets for developing anticancer drugs, recent developments in gene therapy, and the appropriate use of molecular information in genetic counseling.
Up-to-date and forward-looking, The Molecular Basis of Human Cancer offers a critically integrated survey of the full range of state-of-the-art cancer molecular biology and genetics and constitutes indispensable reading for all cancer researchers today.


carcinoma genes molecular biology molecular mechanisms signal transduction

Editors and affiliations

  • William B. Coleman
    • 1
  • Gregory J. Tsongalis
    • 2
  1. 1.Department of Pathology and Laboratory MedicineUniversity of North Carolina School of MedicineChapel HillUSA
  2. 2.Department of Pathology and Laboratory MedicineHartford HospitalHartfordUSA

Bibliographic information

Industry Sectors
Health & Hospitals
Oncology & Hematology