© 2001

Antimalarial Chemotherapy

Mechanisms of Action, Resistance, and New Directions in Drug Discovery

  • Philip J. Rosenthal

Part of the Infectious Disease book series (ID)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Philip J. Rosenthal, Louis H. Miller
      Pages 3-13
    3. Steven R. Meshnick, Mary J. Dobson
      Pages 15-25
    4. Kasturi Haldar, Thomas Akompong
      Pages 27-41
    5. Ritu Banerjee, Daniel E. Goldberg
      Pages 43-63
    6. Piero L. Olliaro, Peter B. Bloland
      Pages 65-83
  3. Established Antimalarial Drugs and Compounds Under Clinical Development

    1. Front Matter
      Pages 85-85
    2. Leann Tilley, Paul Loria, Mick Foley
      Pages 87-121
    3. Ralf P. Brueckner, Colin Ohrt, J. Kevin Baird, Wilbur K. Milhous
      Pages 123-151
    4. Grant Dorsey, David A. Fidock, Thomas E. Wellems, Philip J. Rosenthal
      Pages 153-172
    5. Christopher V. Plowe
      Pages 173-190
    6. Steven R. Meshnick
      Pages 191-201
    7. Akhil B. Vaidya
      Pages 203-218
    8. Piero L. Olliaro, Wilbur K. Milhous
      Pages 219-232
  4. New Compounds, New Approaches, and New Targets

    1. Front Matter
      Pages 233-233
    2. Paul A. Stocks, Kaylene J. Raynes, Stephen A. Ward
      Pages 235-253
    3. Gary H. Posner, Mikhail Krasavin, Michael McCutchen, Poonsakdi Ploypradith, John P. Maxwell, Jeffrey S. Elias et al.
      Pages 255-263
    4. Barbara Clough, R. J. M. Wilson
      Pages 265-286
    5. Pradipsinh K. Rathod
      Pages 287-306

About this book


At a time when the control of malaria is increasingly limited by the growing resistance of malaria parasites to available drugs, the need for a much better use of the existing drugs, as well as for the development of new antimalarials, has become urgent. In Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery, a panel of leading malaria experts drawn from academia, the military, and international health organizations survey the latest scientific understanding of antimalarial chemotherapy, emphasizing the molecular mechanisms of resistance and the description of important new targets. The survey covers the current status of malarial and antimalarial chemotherapy, the relevant biology and biochemistry of malaria parasites, the antimalarial drugs currently available, and new chemical approaches to and possible new targets for chemotherapy. It also discusses, as essential background, the history of chemotherapy, the practical aspects of therapy, and the public health consequences of current problems in antimalarial chemotherapy.
Comprehensive and cutting-edge, Antimalarial Chemotherapy: Mechanisms of Action, Resistance, and New Directions in Drug Discovery clearly delineates all the basic and clinical research now addressing one of the world's major unresolved disease problems, work that is now powerfully driving the rapid pace of antimalarial drug discovery today.


Malaria antibiotics biochemistry chemotherapy clinical research drug drug discovery drug resistance lipide metabolism research resistance

Editors and affiliations

  • Philip J. Rosenthal
    • 1
  1. 1.School of MedicineUniversity of CaliforniaSan FranciscoUSA

Bibliographic information

  • Book Title Antimalarial Chemotherapy
  • Book Subtitle Mechanisms of Action, Resistance, and New Directions in Drug Discovery
  • Editors Philip J. Rosenthal
  • Series Title Infectious Disease
  • DOI
  • Copyright Information Humana Press 2001
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-670-3
  • Softcover ISBN 978-1-61737-124-0
  • eBook ISBN 978-1-59259-111-4
  • Edition Number 1
  • Number of Pages XI, 396
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Infectious Diseases
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Public Health
Internal Medicine & Dermatology


"With contributions from 41 different authors, this book provides a welcome collection of short reviews covering numerous topics in antimalarial chemotherapy. ...this book will offer a useful review for those who study malaria and, more importantly, an entry point into antimalarial chemotherapy for those new in the field." - Journal of Medicinal Chemistry

"...the publication of a new on antimalarial chemotheraphy is very topcial and timely. Philip Rosenthal has put together a very comprehensive book on the current status of research in this important field of medicianl chemistry....The part on established antimalarial drugs covers all drugs currently in clinical application and trials....Special emphasis is put in many articles on aspects of toxicity, therapy, problems, and future developments....the editor has managed to compile the contributions in such a way that a comprehensive picture of the current status emerges and the book feels more like a single-author publication than an edited work....The book is a must for chemists, biologists, and health professionals involved in malaria research." - ChemBioChem

"...thought provoking with its new leads to drug essential addition to the libraries and an essential reading book for malariologists." -The National Journal of India