© 2001

Transgenics in Endocrinology

  • Martin M. Matzuk
  • Chester W. Brown
  • T. Rajendra Kumar

Part of the Contemporary Endocrinology book series (COE)

Table of contents

  1. Front Matter
    Pages i-x
  2. Albert S. Y. Chang, Michael J. Reardon, Francesco J. DeMayo
    Pages 1-18
  3. Deanne J. Whitworth, Richard R. Behringer
    Pages 19-39
  4. Julia A. Elvin, Martin M. Matzuk
    Pages 61-89
  5. Emiliana Borrelli, T. Rajendra Kumar, Paolo Sassone-Corsi
    Pages 91-114
  6. Andrea J. Ross, Grant R. MacGregor
    Pages 115-145
  7. Peter J. Donovan, Maria P. de Miguel
    Pages 147-163
  8. Tomonobu Hasegawa, Liping Zhao, Kathleen M. Caron, Morag Young, Keith L. Parker
    Pages 165-172
  9. John P. Lydon, Selma Soyal, Bert W. O’Malley, Preeti M. Ismail
    Pages 173-204
  10. Nelson D. Horseman
    Pages 231-244
  11. Larry J. Young, Thomas R. Insel
    Pages 245-260
  12. Ruth A. Keri, John H. Nilson
    Pages 261-295
  13. Malcolm J. Low, Marcelo Rubinstenin, E. Cheng Chan
    Pages 319-337
  14. Carolyn A. Bondy, Domenico Accili
    Pages 371-384
  15. Thomas Günther, Mary Jo Doherty, Gerard Karsenty
    Pages 385-399
  16. Robert J. Matusik, Naoya Masumori, Tania Thomas, Thomas Case, Manik Paul, Susan Kasper et al.
    Pages 401-425

About this book


Transgenic mouse technology, including embryonic stem cell and gene knockout techniques, has revolutionized the study of endocrinology by giving endocrinologists an effective set of tools for understanding endocrine physiology and pathology in vivo. In Transgenics in Endocrinology, a panel of expert clinical and basic investigators summarize the state-of-the-art in the use of this powerful technology in a broad range of endocrinological applications. These applications include studies of mammalian sexual differentiation, steroidogenesis, progesterone action in vivo, normal mammary gland development, oxytocin and vasopressin, regulation and function, skeletal biology, and prostate cancer. There are also transgenic studies of the control of ovarian function, the Bcl2 gene family, c-kit/kit ligand axis in mammalian gametogenesis, prolactin and the prolactin receptor, insulin and insulin-like growth factors, and overexpression and targeted disruption of genes involved in the control of growth, food intake, and obesity.
Up-to-date and comprehensive, Transgenics in Endocrinology reviews the most recent developments in the analysis of endocrine physiology, and its pathologies, through mouse models, and provides a host of creative approaches to better understand the complex processes characteristic of hormonal systems.


growth factor insulin insulin-like physiology prolactin protein hormones

Editors and affiliations

  • Martin M. Matzuk
    • 1
  • Chester W. Brown
    • 2
  • T. Rajendra Kumar
    • 3
  1. 1.Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human GeneticsBaylor College of MedicineHoustonUSA
  2. 2.Department of Molecular and Human GeneticsBaylor College of MedicineHoustonUSA
  3. 3.Departments of Pathology, and Molecular and Cellular BiologyBaylor College of MedicineHoustonUSA

Bibliographic information

  • Book Title Transgenics in Endocrinology
  • Editors Martin Matzuk
    Chester W. Brown
    T. Rajendra Kumar
  • Series Title Contemporary Endocrinology
  • DOI
  • Copyright Information Humana Press 2001
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-764-9
  • Softcover ISBN 978-1-4684-9640-6
  • eBook ISBN 978-1-59259-102-2
  • Edition Number 1
  • Number of Pages X, 486
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Endocrinology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


"The three editors have done a wonderful job in getting experts in the field to review their respective areas for publication in one book. . .Basic scientists in endocrinology will find this an important book as it puts together in one book areas that they might not otherwise be able to find summarized so well. Clinical scientists and clinicians will welcome the book for the insights into endocrine mechanisms. . .The index is very helpful as a resource to determine if a particular hormone or factor has been discussed in the book." -Doody's Health Sciences Book Review Journal

"I found the chapter on skeleton biology particularly fascinating. This provides an excellent review of processes and genes involved in bone pattering and development...this is a fascinating text and a great read." -The Endocrinologist