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Tumor Models in Cancer Research

  • Book
  • © 2002

Overview

Editors:
  1. Beverly A. Teicher

    1. Lilly Research Laboratories, Indianapolis, USA

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (34 chapters)

  1. Mutant, Transgenic, and Knockout Mouse Models

    1. The Utility of Transgenic Mouse Models for Cancer Prevention Research

      • Stephen D. Hursting, Ronald A. Lubet
      Pages 263-274

  2. Metastasis Models

    1. Front Matter

      Pages 275-275
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    2. Metastasis Models

      • Krishna Menon, Beverly A. Teicher
      Pages 277-291

    3. Models for Evaluation of Targeted Therapies of Metastatic Disease

      • Suzanne A. Eccles
      Pages 293-319

  3. Normal Tissue Response Models

    1. Front Matter

      Pages 321-321
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    2. Animal Models of Oral Mucositis Induced by Antineoplastic Drugs and Radiation

      • Stephen T. Sonis
      Pages 323-335

    3. The Intestine as a Model for Studying Stem-Cell Behavior

      • Catherine Booth, Christopher S. Potten
      Pages 337-357

    4. SENCAR Mouse-Skin Tumorigenesis Model

      • Rana P. Singh, Rajesh Agarwal
      Pages 359-380

    5. Murine Models of Bone-Marrow Transplant Conditioning

      • Ronald van Os, Julian D. Down
      Pages 381-405

    6. Anesthetic Considerations for the Study of Murine Tumor Models

      • Robert E. Meyer, Rod D. Braun, Mark W. Dewhirst
      Pages 407-431

  4. Disease and Target-Specific Models

    1. Front Matter

      Pages 433-433
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    2. Tissue-Isolated Tumors in Mice

      • Paul E. G. Kristjansen
      Pages 435-451

    3. Human Breast-Cancer Xenografts as Models of the Human Disease

      • Robert Clarke
      Pages 453-470

    4. Animal Models of Melanoma

      • William E. Carson III, Michael J. Walker
      Pages 471-492

    5. Experimental Animal Models for Renal Cell Carcinoma

      • Gilda G. Hillman
      Pages 493-505

    6. Animal Models of Mesothelioma

      • Harvey I. Pass, Orlin Hadjiev, Michele Carbone
      Pages 507-520

    7. SCID Mouse Models of Human Leukemia and Lymphoma as Tools for New Agent Development

      • Fatih M. Uckun, Martha G. Sensel
      Pages 521-540

    8. Models for Studying the Action of Topoisomerase-I Targeted Drugs

      • Joyce Thompson, Clinton F. Stewart, Peter J. Houghton
      Pages 541-563

    9. Spontaneous Pet Animal Cancers

      • Mark W. Dewhirst, Donald Thrall, E. Gregory MacEwen
      Pages 565-589

  5. Experimental Methods and End Points

    1. Front Matter

      Pages 591-591
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Keywords

About this book

Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in animal tumor model research. The wide array of models detailed form the basis for the selection of compounds and treatments that go into clinical testing of patients, and include syngeneic models, human tumor xenograft models, orthotopic models, metastatic models, transgenic models, and gene knockout models. Synthesizing many years experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Reviews

"...the book synthesizes years of knowledge on all major models available for cancer research. As a first comprehensive summary on tumor models in many years, it is certainly a good reference to those working in preclinical and clinical cancer research and drug development." -Pharmaceutical Research

"This publication belongs to the successful book series "Cancer Drug Discovery and Development™." The book provides an excellent guide over the experimental procedures developed in attempt to improve the treatment of malignancies. This publication represents an outstanding work devoted to the current state-of-the-art of the in vivo tumor models available for cancer research. The book will be of interest to oncologists, clinical and experimental cancer researchers. Practical approaches presented in the book, provide a guide to maximize the benefit for clinical anticancer treatment." - Neoplasma

Editors and Affiliations

  • Lilly Research Laboratories, Indianapolis, USA

    Beverly A. Teicher

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