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© 2002

Tumor Models in Cancer Research

  • Beverly A. Teicher
Book

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Steadman Harrison
      Pages 3-19
  3. Transplantable Syngeneic Rodent Tumors

    1. Front Matter
      Pages 21-21
    2. Donald J. Dykes, William R. Waud
      Pages 23-40
    3. Thomas H. Corbett, Lisa Polin, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White et al.
      Pages 41-71
    4. Enrique Alvarez
      Pages 73-89
  4. Human Tumor Xenografts

    1. Front Matter
      Pages 91-91
    2. Robert M. Hoffman
      Pages 99-112
    3. Heinz-Herbert Fiebig, Angelika M. Burger
      Pages 113-137
  5. Carcinogen-Induced Tumors

    1. Front Matter
      Pages 139-139
    2. Joel Schwartz, Xinbin Gu
      Pages 141-171
    3. Henry J. Thompson, Michael B. Sporn
      Pages 173-181
  6. Mutant, Transgenic, and Knockout Mouse Models

    1. Front Matter
      Pages 193-193
    2. John J. Letterio
      Pages 195-222
    3. Oliver G. Opitz, Hiroshi Nakagawa, Anil K. Rustgi
      Pages 223-230
    4. Sundaresan Venkatachalam, Stuart Tyner, Lawrence A. Donehower
      Pages 247-261

About this book

Introduction

Cancer researchers have made significant progress over the years by developing appropriate and accurate animal disease models, the most important being transplantable rodent tumors. In Tumor Models in Cancer Research, Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in tumor model research. The wide array of model systems detailed form the basis for the selection of both compounds and treatments that go into clinical testing of patients, and include syngeneic, human tumor xenograft, orthotopic, metastatic, transgenic, and gene knockout models. These models represent the efforts of many investigators over the years and approach, with increasing precision, examples that serve as guides for the selection of agents and combinations for the treatment of human malignancy.
Synthesizing many years of experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Keywords

Antigen apoptosis carcinoma imaging metastatic disease transplantation tumorigenesis

Editors and affiliations

  • Beverly A. Teicher
    • 1
  1. 1.Lilly Research LaboratoriesIndianapolisUSA

Bibliographic information

  • Book Title Tumor Models in Cancer Research
  • Editors Beverly A. Teicher
  • Series Title Cancer Drug Discovery and Development
  • DOI https://doi.org/10.1007/978-1-59259-100-8
  • Copyright Information Humana Press 2002
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-887-5
  • Softcover ISBN 978-1-4757-6883-1
  • eBook ISBN 978-1-59259-100-8
  • Edition Number 1
  • Number of Pages XV, 690
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Pharmacology/Toxicology
  • Buy this book on publisher's site
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Reviews

"...the book synthesizes years of knowledge on all major models available for cancer research. As a first comprehensive summary on tumor models in many years, it is certainly a good reference to those working in preclinical and clinical cancer research and drug development." -Pharmaceutical Research

"This publication belongs to the successful book series "Cancer Drug Discovery and Development™." The book provides an excellent guide over the experimental procedures developed in attempt to improve the treatment of malignancies. This publication represents an outstanding work devoted to the current state-of-the-art of the in vivo tumor models available for cancer research. The book will be of interest to oncologists, clinical and experimental cancer researchers. Practical approaches presented in the book, provide a guide to maximize the benefit for clinical anticancer treatment." - Neoplasma