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Tumor Models in Cancer Research

  • Beverly A. Teicher

Part of the Cancer Drug Discovery and Development book series (CDD&D)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Steadman Harrison
      Pages 3-19
  3. Transplantable Syngeneic Rodent Tumors

    1. Front Matter
      Pages 21-21
    2. Donald J. Dykes, William R. Waud
      Pages 23-40
    3. Thomas H. Corbett, Lisa Polin, Bill J. Roberts, Alfred J. Lawson, Wilbur R. Leopold III, Kathryn White et al.
      Pages 41-71
    4. Enrique Alvarez
      Pages 73-89
  4. Human Tumor Xenografts

    1. Front Matter
      Pages 91-91
    2. Robert M. Hoffman
      Pages 99-112
    3. Heinz-Herbert Fiebig, Angelika M. Burger
      Pages 113-137
  5. Carcinogen-Induced Tumors

    1. Front Matter
      Pages 139-139
    2. Joel Schwartz, Xinbin Gu
      Pages 141-171
    3. Henry J. Thompson, Michael B. Sporn
      Pages 173-181
  6. Mutant, Transgenic, and Knockout Mouse Models

    1. Front Matter
      Pages 193-193
    2. John J. Letterio
      Pages 195-222
    3. Oliver G. Opitz, Hiroshi Nakagawa, Anil K. Rustgi
      Pages 223-230
    4. Sundaresan Venkatachalam, Stuart Tyner, Lawrence A. Donehower
      Pages 247-261
    5. Stephen D. Hursting, Ronald A. Lubet
      Pages 263-274
  7. Metastasis Models

    1. Front Matter
      Pages 275-275
    2. Krishna Menon, Beverly A. Teicher
      Pages 277-291
  8. Normal Tissue Response Models

    1. Front Matter
      Pages 321-321
    2. Catherine Booth, Christopher S. Potten
      Pages 337-357
    3. Rana P. Singh, Rajesh Agarwal
      Pages 359-380
    4. Ronald van Os, Julian D. Down
      Pages 381-405
    5. Robert E. Meyer, Rod D. Braun, Mark W. Dewhirst
      Pages 407-431
  9. Disease and Target-Specific Models

    1. Front Matter
      Pages 433-433
    2. Paul E. G. Kristjansen
      Pages 435-451
    3. William E. Carson III, Michael J. Walker
      Pages 471-492
    4. Harvey I. Pass, Orlin Hadjiev, Michele Carbone
      Pages 507-520
    5. Joyce Thompson, Clinton F. Stewart, Peter J. Houghton
      Pages 541-563
    6. Mark W. Dewhirst, Donald Thrall, E. Gregory MacEwen
      Pages 565-589
  10. Experimental Methods and End Points

    1. Front Matter
      Pages 591-591
    2. Beverly A. Teicher
      Pages 593-616
    3. Sara Rockwell
      Pages 617-631
    4. L. Clifton Stephens, Raymond E. Meyn
      Pages 633-645
    5. Rakesh K. Jain, Lance L. Munn, Dai Fukumura
      Pages 647-671
  11. Back Matter
    Pages 673-690

About this book

Introduction

Cancer researchers have made significant progress over the years by developing appropriate and accurate animal disease models, the most important being transplantable rodent tumors. In Tumor Models in Cancer Research, Beverly A. Teicher and a panel of leading experts comprehensively describe for the first time in many years the state-of-the-art in tumor model research. The wide array of model systems detailed form the basis for the selection of both compounds and treatments that go into clinical testing of patients, and include syngeneic, human tumor xenograft, orthotopic, metastatic, transgenic, and gene knockout models. These models represent the efforts of many investigators over the years and approach, with increasing precision, examples that serve as guides for the selection of agents and combinations for the treatment of human malignancy.
Synthesizing many years of experience with all the major in vivo models currently available for the study of malignant disease, Tumor Models in Cancer Research provides preclinical and clinical cancer researchers alike with a comprehensive guide to the selection of these models, their effective use, and the optimal interpretation of their results.

Keywords

Antigen apoptosis carcinoma imaging metastatic disease transplantation tumorigenesis

Editors and affiliations

  • Beverly A. Teicher
    • 1
  1. 1.Lilly Research LaboratoriesIndianapolisUSA

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