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Therapeutic Interventions in the Complement System

  • John D. Lambris
  • V. Michael Holers

Part of the Contemporary Immunology book series (CONTIM)

Table of contents

  1. Front Matter
    Pages i-x
  2. Sthanam V. L. Narayana, Y. Sudhakara Babu, John E. Volanakis
    Pages 57-74
  3. Arvind Sahu, Dimitrios Morikis, John D. Lambris
    Pages 75-112
  4. Patricia C. Giclas
    Pages 225-236
  5. Peter A. Ward, Boris J. Czermak, Markus Huber-Lang, Katherine Diehl, Hans P. Friedl
    Pages 237-253
  6. Back Matter
    Pages 255-259

About this book

Introduction

Although the complement system is a vital part of the body's defenses against bacteria, its inappropriate activation produces the cell damage found in a wide variety of illnesses, ranging from hemolytic anemia to multiple sclerosis. In Therapeutic Interventions in the Complement System, a team of expert investigators and researchers comprehensively review complement's basic biology, its role in disease, methods to measure its activity, and strategies for its inhibition in patients. Each chapter focuses on a specific area of basic and applied complement biology, detailing the activation pathways and complement receptors. Informative animal models are thoroughly discussed, including the relative values of each model and the important interspecies differences that can distort the interpretation of preclinical studies. Also discussed are analytical issues concerning the sensitivity and specificity of the important new ELISA assays for measuring complement. Throughout, the emphasis is on the pros and cons of the use of recombinant complement inhibitors as therapeutics in specific diseases.
Cutting-edge and innovative, Therapeutic Interventions in the Complement System highlights for clinical researchers and biotechnologists the powerful drug discovery and development strategies that are producing the novel complement inhibitors today emerging for the treatment of a wide variety of clinically important diseases.

Keywords

biology clinical research diseases drug drug discovery inflammation research

Editors and affiliations

  • John D. Lambris
    • 1
  • V. Michael Holers
    • 2
  1. 1.University of Pennsylvania School of MedicinePhiladelphiaUSA
  2. 2.University of Colorado Health Sciences CenterDenverUSA

Bibliographic information

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