© 2000

Human Growth Hormone

Research and Clinical Practice

  • Roy G. Smith
  • Michael O. Thorner

Part of the Contemporary Endocrinology book series (COE, volume 19)

Table of contents

  1. Front Matter
    Pages i-x
  2. Overview of Human Growth Hormone

    1. Roy G. Smith
      Pages 1-13
  3. Research

    1. Front Matter
      Pages 15-15
    2. C. Y. Bowers
      Pages 17-43
    3. Arthur A. Patchett, Matthew J. Wyvratt
      Pages 45-67
    4. Andrew D. Howard, Scott D. Feighner, Roy G. Smith, Lex H. T. Van der Ploeg
      Pages 69-84
    5. Gurkeerat Singh, George Liapakis, Terry Reisine
      Pages 109-117
    6. David Brown, Elinor A. Stephens, Gareth Leng, Roy G. Smith
      Pages 119-130
    7. Kenneth H. Pearce, James A. Wells
      Pages 131-143
    8. Pamela A. Bennett, Iain C. A. F. Robinson
      Pages 145-166
  4. Clinical Practice

    1. Front Matter
      Pages 167-167
    2. Linda Anne DiMeglio, Paul L. Hofman, Ora Hirsch Pescovitz
      Pages 169-190
    3. Barry B. Bercu, Howard J. Heinze
      Pages 191-219
    4. Paul V. Carroll, Emanuel R. Christ, Peter H. Sönksen
      Pages 221-232
    5. Howard B. A. Baum, Anne Klibanski
      Pages 233-245
    6. Gudmundur Johannsson, Per Mårin, Jan-Ove Johansson, Bengt Åke Bengtsson
      Pages 247-260
    7. Eve Van Cauter, Georges Copinschi
      Pages 261-283
    8. Kathleen Mulligan, Morris Schambelan
      Pages 285-295

About this book


In Human Growth Hormone: Research and Clinical Ptractice, Roy Smith and a distinguished panel of researchers and clinicians combine a review of GH regulation and its action at the molecular level with a state-of-the-art description of the basis for GH deficiency and the use of GH therapy in a variety of clinical situations. The clinical uses of GH discussed here move beyond the treatment of GH-deficient children to include the genetics of GH-deficiency, GH-deficiency in adults, osteoporosis, Syndrome X, sleep quality, GH in AIDS patients, and GHRH in clinical studies. Also described are a family of GH-secretagogues that bind to a new orphan receptor controlling the physiology of GH release. The discussion of the new GH therapeutics includes their design, their action as regulators in the pituitary gland and in the central nervous system, and their use as new agents for treating growth hormone deficiency states.

Human Growth Hormone: Research and Clinical Practice offers an unprecedented cutting-edge synthesis of basic science and clinical practice. Timely and innovative, this book will benefit both basic and clinical researchers, as well as those clinical endocrinologists who want to use growth hormone not only in treating children, but also in treating adult disorders, including those associated with metabolic disease.


growth growth hormone hormone

Editors and affiliations

  • Roy G. Smith
    • 1
  • Michael O. Thorner
    • 2
  1. 1.Huffington Center on Aging and Department of Cell BiologyBaylor College of MedicineHoustonUSA
  2. 2.Department of MedicineUniversity of Virginia Health Sciences CenterCharlottesvilleUSA

Bibliographic information

  • Book Title Human Growth Hormone
  • Book Subtitle Research and Clinical Practice
  • Editors Roy G. Smith
    Michael O. Thorner
  • Series Title Contemporary Endocrinology
  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-505-8
  • Softcover ISBN 978-1-4684-9610-9
  • eBook ISBN 978-1-59259-015-5
  • Edition Number 1
  • Number of Pages X, 348
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Endocrinology
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology


"This book is designed as a summary of the basic and clinical aspects of the regulation of GH axis as well as the effects of GH in catabolic conditions and GH deficiency. . .Particularly good are the basic chapters on the design of GH secretagogues, structure and function of GH receptor, and the CNS effects of GH. The chapter on interrelations between GH secretion and sleep is superb in that it is a brief but comprehensive treatment of the topic. . . This is a good summary of some novel aspects of basic GH research."-Doody's Health Science Book Review Journal

"A concise, well written, amply illustrated and referenced text." -Journal of Pediatric Endocrinology & Metabolism

"Human Growth Hormones: Research and Clinical Practice fulfills every expectation of excellence, largely as a result of the outstanding caliber of the contributors....the volume blends the basic-science elements of secretagogue discovery with the investigative clinical applications of GHRHs and GHRPs in the thorough and thoughtful manner....Central nervous system (CNS) actions of GHRH and GHRP agonists are presented in two outstanding chapters, followed b a brief but comprehensible biomathematical model of agonist-receptor-driven GH secretion as modulated by somatostatin restraint. The overview of pediatric neuroendocrinology by Bercu et al. is comprehensive and articulate....The illustrations throughout the text are plentiful and superb....As a clinical neuroendocrinologist working in the arena of GH pathophysiology, and teaching at the basic fellowship level, I regard this as one of the bright stars among scholarly updates for clinicians, research fellows and senior scientists"-Trends in Endocrinology and Metabolism