Molecular Mechanisms of Neurodegenerative Diseases

  • Marie-Françoise Chesselet

Part of the Contemporary Clinical Neuroscience book series (CCNE)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. William L. Klein
    Pages 1-49
  3. Michael C. Sugarman, Steven F. Hinton, Frank M. LaFerla
    Pages 51-72
  4. Robert E. Mrak, W. Sue T. Griffin
    Pages 73-86
  5. Caleb E. Finch, Valter Longo, Aya Miyao, Todd E. Morgan, Irina Rozovsky, Yubei Soong et al.
    Pages 87-110
  6. Vivian Y. H. Hook, Liane Mende-Mueller
    Pages 111-129
  7. Michael Gold, Kevin M. Felsenstein, Perry Molinoff
    Pages 131-149
  8. Benoit I. Giasson, Christina A. Wilson, John Q. Trojanowski, Virginia M. Y. Lee
    Pages 151-176
  9. Tamara Hershey, Stephen M. Moerlein, Joel S. Perlmutter
    Pages 177-193
  10. BethAnn McLaughlin
    Pages 195-231
  11. Russell H. Swerdlow
    Pages 233-270
  12. Harry T. Orr, Huda Y. Zoghbi
    Pages 271-283
  13. Puneet Opal, Henry Paulson
    Pages 285-306
  14. Marie-Françoise Chesselet, Michael S. Levine
    Pages 327-346
  15. Marcy E. MacDonald, Lucius Passani, Paige Hilditch-Maguire
    Pages 347-372
  16. Back Matter
    Pages 407-410

About this book


With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases.
Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.


Alzheimer PET Parkinson alzheimer's disease inflammation neurodegenerative disorders pathophysiology physiology positron emission tomography (PET)

Authors and affiliations

  • Marie-Françoise Chesselet
    • 1
  1. 1.Reed Neurological Research Center, School of MedicineUniversity of California, Los AngelesLos AngelesUSA

Bibliographic information

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