© 2000

Early Diagnosis of Alzheimer’s Disease

  • Leonard F. M. Scinto
  • Kirk R. Daffner

Part of the Current Clinical Neurology book series (CCNEU)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Kirk R. Daffner, Leonard F. M. Scinto
    Pages 1-27
  3. Dennis J. Selkoe
    Pages 83-104
  4. Deborah Blacker, Rudolph E. Tanzi
    Pages 105-125
  5. Clifford R. Jack Jr., Ronald C. Petersen
    Pages 127-148
  6. Reisa A. Sperling, Thomas A. Sandson, Keith A. Johnson
    Pages 149-168
  7. Dorene M. Rentz, Sandra Weintraub
    Pages 169-189
  8. Maire E. Percy, David F. Andrews, Huntington Potter
    Pages 191-268
  9. Kenneth S. Kosik, Stephen G. Post, Kimberly A. Quaid
    Pages 317-327
  10. Back Matter
    Pages 329-359

About this book


Strategies for the early diagnosis of Alzheimer's disease are among the most important and most discussed topics in dementia care today. In Early Diagnosis of Alzheimer's Disease, Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of today's new diagnostic approaches to Alzheimer's disease. Leaders in the field critically survey the most promising clinical research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. In addition, there are reviews of current clinical practice in the diagnosis of Alzheimer's disease, the major theories about its pathophysiology, and the therapeutic and ethical implications of early diagnosis. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this highly prevalent disease. Addressed to clinicians caring for an aging population, researchers developing new therapeutics, and policymakers concerned about the impact of early diagnosis on the delivery of health care, this timely, state-of-the-art volume constitutes a new standard reference guide for all those working with Alzheimer's patients today.


Alzheimer PET SPECT alzheimer's disease brain magnetic resonance imaging (MRI) neuropathology pathophysiology physiology positron emission tomography (PET)

Editors and affiliations

  • Leonard F. M. Scinto
    • 1
  • Kirk R. Daffner
    • 1
  1. 1.Department of Neurology, Brigham and Women’s HospitalHarvard Medical SchoolBostonUSA

Bibliographic information

  • Book Title Early Diagnosis of Alzheimer’s Disease
  • Editors Leonard F. M. Scinto
    Kirk R. Daffner
  • Series Title Current Clinical Neurology
  • DOI
  • Copyright Information Humana Press 2000
  • Publisher Name Humana Press, Totowa, NJ
  • eBook Packages Springer Book Archive
  • Hardcover ISBN 978-0-89603-452-5
  • Softcover ISBN 978-1-4684-9601-7
  • eBook ISBN 978-1-59259-005-6
  • Edition Number 1
  • Number of Pages XIII, 359
  • Number of Illustrations 0 b/w illustrations, 0 illustrations in colour
  • Topics Neurology
  • Buy this book on publisher's site
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"This volume on the early diagnosis of Alzheimer's disease is both timely and compelling. It offers contributions from a superb group of experts who have helped define the relevant issues and led critical clinical and scientific advances in early-stage diagnosis. The first three chapters justify the importance of accurate diagnosis and describe the clinical and pathological phenotypes for early-stage Alzheimer's disease. . . The Editors are to be commended for the extraordinarily high quality of the contributing authors and for focusing attention on the topic of early-stage Alzheimer's disease. . . the early diagnosis of Alzheimer's disease will become a dominant issue for clinicians, patients, and their families as new therapies are developed and new research discoveries occur. This volume not only serves as a testimonial to the value of early diagnosis, but provides clinicians and scientists with the basis to appreciate ongoing developments in this emerging and important field." -Foreword by John C. Morris, MD, Professor of Neurology, Washington University School of Medicine

"The editors and authors of this book have produced an important, timely and accessible review of developments in early diagnosis. They rightly highlight the increasing focus on the idea that mild cognitive impairment, previously thought to be caused by a normal sign of aging , may actually be a sign of incipient or very mild AD. The contributors all stress the practical implications of the evidence and data they review...with both practical clinical advice, plus detailed and referenced discussion of the research to date, this book should prove invaluable to physicians and scientists alike."- Pathways: The Novartis Journal

"This volume is a valuable resource essentially for the clinicians (neurologists, neuropsychiatrists, neurogeriatrists) and the scientists whose principal interest is Alzheimer's disease (AD)....contains the contributions of excellent experts with the aim to introduce a detailed, extensive but nonredundant summary regarding methods and results of research on the early stages of AD....The reading is easy an d the aspects of early diagnosis are treated with a coherent and unitary method....I highly recommend this book as a most valuable and unitary reference regarding the actual knowledge of early diagnosis of AD."- European Neurology

"The book's value as a single volume is carried by the diversity of material covered and the compendium of references for each chapter, all taken from the point of view of the importance of early diagnosis." - Journal of the International Neuropsychological Society

"...this is a text which is uniformly well-written, ably edited by Leonard Scinto and Kirk Daffner and will certainly be frequently dipped into by researchers. I recommend it for university libraries and for researchers in this area." - International Journal of Geriatric Psychiatry

"The text is authoritative, extremely well-referenced and I really think it is geared towards researchers in the field. I learnt a tremendous amount from reading this text...I recommend it for university libraries and for researchers in this area." -International Journal of Geriatric Psychiatry