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NMR-Based Metabolomics

Methods and Protocols

  • G. A. Nagana Gowda
  • Daniel Raftery
Book

Part of the Methods in Molecular Biology book series (MIMB, volume 2037)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. Historical and Methodological Overview

    1. Front Matter
      Pages 1-1
  3. Metabolite Analysis Methods

    1. Front Matter
      Pages 15-15
    2. Miriam Gil, Sara Samino, Rubén Barrilero, Xavier Correig
      Pages 35-47
    3. Marlon Tilgner, Tim S. Vater, Piet Habbel, Leo L. Cheng
      Pages 49-67
    4. Arthur S. Edison, Adrien Le Guennec, Frank Delaglio, Ēriks Kupče
      Pages 69-95
  4. Unknown Resonance Identification

    1. Front Matter
      Pages 111-111
    2. Abhinav Dubey, Shivanand M. Pudakalakatti, Hanudatta S. Atreya
      Pages 135-147
  5. Stable Isotope-Resolved NMR

    1. Front Matter
      Pages 149-149
    2. Penghui Lin, Andrew N. Lane, Teresa W.-M. Fan
      Pages 151-168
  6. Biomarker Discovery

    1. Front Matter
      Pages 187-187
    2. Julian L. Griffin, Cecilia Castro
      Pages 189-194
    3. Uma Sharma, Naranamangalam R. Jagannathan
      Pages 195-213
    4. Tedros Bezabeh, Ana Capati, Omkar B. Ijare
      Pages 215-229
    5. Renuka Ranjan, Neeraj Sinha
      Pages 231-241
    6. Maria T. Grinde, Guro F. Giskeødegård, Trygve Andreassen, May-Britt Tessem, Tone F. Bathen, Siver A. Moestue
      Pages 243-262
  7. Drug Discovery

    1. Front Matter
      Pages 263-263
    2. Fatema Bhinderwala, Robert Powers
      Pages 265-311
  8. Environmental Studies

  9. Food, Nutrition, and Plants

    1. Front Matter
      Pages 333-333
    2. Ulrik K. Sundekilde, Nina Eggers, Hanne Christine Bertram
      Pages 335-344
    3. Denise Medeiros Selegato, Alan Cesar Pilon, Fausto Carnevale Neto
      Pages 345-362
  10. Ultrafast and Ultrahigh-Resolution Methods

    1. Front Matter
      Pages 363-363
    2. Estelle Martineau, Patrick Giraudeau
      Pages 365-383
    3. Mathilde H. Lerche, Magnus Karlsson, Jan H. Ardenkjær-Larsen, Pernille R. Jensen
      Pages 385-393
    4. Maryam Tabatabaei Anaraki, Daniel Lane, Monica Bastawrous, Amy Jenne, André J. Simpson
      Pages 395-409
  11. Automation, Databases and Software Tools

    1. Front Matter
      Pages 411-411
    2. John L. Markley, Hesam Dashti, Jonathan R. Wedell, William M. Westler, Hamid R. Eghbalnia
      Pages 413-427
    3. Matthias Lipfert, Manoj Kumar Rout, Mark Berjanskii, David S. Wishart
      Pages 429-449
  12. Data Processing and Statistical Methods

    1. Front Matter
      Pages 451-451
    2. Timothy M. D. Ebbels, Ibrahim Karaman, Gonçalo Graça
      Pages 453-470
    3. Dabao Zhang, Min Zhang
      Pages 471-482
  13. Back Matter
    Pages 483-489

About this book

Introduction

This book provides broad coverage of nuclear magnetic resonance (NMR) spectroscopy-based methods and applications for the analysis of metabolites in a wide range of biological samples, from biofluids, cells, animal models, human, to plants and foods. The applications range from mechanistic understanding, biomarker discovery, environmental studies, and drug discovery to nutrition, while NMR methods include global, targeted, and isotope tracer-based techniques. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, NMR-Based Metabolomics: Methods and Protocols serves as a wealth of information for beginners as well as advanced practitioners and also as stepping stones for further advances in the field of metabolomics.

Keywords

Nuclear magnetic resonance spectroscopy Metabolite analysis Biological samples Biomarker discovery Drug discovery Data analysis

Editors and affiliations

  • G. A. Nagana Gowda
    • 1
  • Daniel Raftery
    • 2
  1. 1.Northwest Metabolomics Research Center, Mitochondria and Metabolism Center, Department of Anesthesiology and Pain MedicineUniversity of WashingtonSeattleUSA
  2. 2.Northwest Metabolomics Research Center, Mitochondria and Metabolism Center, Department of Anesthesiology and Pain MedicineUniversity of Washington, Fred Hutch Cancer Research CenterSeattleUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-9690-2
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9689-6
  • Online ISBN 978-1-4939-9690-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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