Genotoxicity Assessment

Methods and Protocols

  • Alok Dhawan
  • Mahima Bajpayee

Part of the Methods in Molecular Biology book series (MIMB, volume 2031)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Gene Mutation Assays

    1. Front Matter
      Pages 1-1
    2. Melissa R. Schisler, Martha M. Moore, B. Bhaskar Gollapudi
      Pages 3-28
    3. Jeffrey C. Bemis, Nikki E. Hall, Stephen D. Dertinger
      Pages 29-57
    4. Vasily N. Dobrovolsky, Joseph G. Shaddock, Roberta A. Mittelstaedt, Daishiro Miura, Robert H. Heflich
      Pages 59-75
  3. Assays for Chromosomal Abnormalities

    1. Front Matter
      Pages 77-77
    2. Christian Johannes, Guenter Obe
      Pages 121-134
    3. Abhishek Kumar Jain, Alok Kumar Pandey
      Pages 135-146
    4. Claudia Bolognesi, Michael Fenech
      Pages 147-163
    5. Azeddine Elhajouji, Pascal Stadelmann
      Pages 165-193
    6. Kerstin Reisinger, Eva Dony, Thorsten Wolf, Katrin Maul
      Pages 195-208
    7. Adi Baumgartner, Veronika Hartleb, Jim D. Taylor
      Pages 209-234
  4. Tests for Primary DNA Damage

    1. Front Matter
      Pages 235-235
    2. Mahima Bajpayee, Ashutosh Kumar, Alok Dhawan
      Pages 237-257
    3. Diana Anderson, Alok Dhawan, Julian Laubenthal
      Pages 259-274
    4. Patrizia Guidi, Brett P. Lyons, Giada Frenzilli
      Pages 275-286
    5. Julian Laubenthal, Michal R. Gdula, Alok Dhawan, Diana Anderson
      Pages 287-300
    6. Vipin Kumar Yadav, Poorwa Awasthi, Amit Kumar
      Pages 313-322
  5. Assays in Plants and Alternate Animal Models

    1. Front Matter
      Pages 323-323
    2. Miroslav Mišík, Clemens Pichler, Bernhard Rainer, Armen Nersesyan, Katarína Mišíková, Siegfried Knasmueller
      Pages 325-335
  6. In Silico Testing for Genetic Toxicology

    1. Front Matter
      Pages 349-349
    2. Meetali Sinha, Alok Dhawan, Ramakrishnan Parthasarathi
      Pages 351-373
  7. Back Matter
    Pages 375-378

About this book


This current edition explores new tests for genotoxicity testing, along with other well-known techniques. This will further help in our understanding of the genotoxic effects of chemicals. The book has different sections dealing with various assays for gene mutation, chromosomal abnormalities, primary DNA damage, etc. It also delves into plant models, animals and their alternates, as well as in silico approaches for genetic toxicology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, tips on troubleshooting and avoiding known pitfalls. 

Authoritative and up-to-date, Genotoxicity Assessment: Methods and Protocols, Second Edition serves as a highly useful and ready resource for research students and scientists working in regulatory toxicology as well as biomedical, biochemical, and pharmaceutical sciences.


Genetic toxicology Mutation assays DNA damage Chromosomal abnormalities Toxicogenomics Computational predictive models

Editors and affiliations

  • Alok Dhawan
    • 1
  • Mahima Bajpayee
    • 2
  1. 1.CSIR—Indian Institute of Toxicology ResearchLucknowIndia
  2. 2.New DelhiIndia

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9645-2
  • Online ISBN 978-1-4939-9646-9
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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