Cyclic Peptide Design

  • Gilles Goetz

Part of the Methods in Molecular Biology book series (MIMB, volume 2001)

Table of contents

  1. Front Matter
    Pages i-x
  2. Bhavesh Khatri, Venkateswara Rao Nuthakki, Jayanta Chatterjee
    Pages 17-40
  3. George Appiah Kubi, Patrick G. Dougherty, Dehua Pei
    Pages 41-59
  4. Fergal Duffy, Nikunj Maheshwari, Nicolae-Viorel Buchete, Denis Shields
    Pages 73-95
  5. Licheng Tu, Dongyuan Wang, Zigang Li
    Pages 107-131
  6. Adel Ahmed Rashad
    Pages 133-145
  7. Philipp Ermert, Anatol Luther, Peter Zbinden, Daniel Obrecht
    Pages 147-202
  8. Kazimierz Wiśniewski
    Pages 235-271
  9. Zhengrong Zhu, Alex Shaginian, La Shadric C. Grady, Christopher P. Davie, Kenneth Lind, Sandeep Pal et al.
    Pages 273-284
  10. Anthony Pitt, Zeke Nims
    Pages 285-298
  11. Christos Tsiamantas, Manuel E. Otero-Ramirez, Hiroaki Suga
    Pages 299-315
  12. Back Matter
    Pages 329-332

About this book


This book covers strategies to improve cell permeability, intestinal permeability, and metabolic stability, which are the typical liabilities associated with cyclic peptides, to enhance protein-protein recognition, and to build upon nature’s cyclic peptides and macrocycles. Chapters also cover key peptide screening and display strategies, as well as important synthetic approaches towards cyclic and helical peptides. Cyclic peptides have become of significant importance as chemical tools in biology and drug discovery, since this class of chemicals has become a credible alternative source of new drug leads on par with traditional small molecules. As a part of the Methods in Molecular Biology series, this collection includes the kind of detail and implementation advice to aid researchers in the field. 

Authoritative and cutting-edge, Cyclic Peptide Design serves as a critical resource and go-to reference for researchers within the pharmaceutical industry, as well as scientists and students in the bioorganic, medicinal, and natural product chemistry fields.


Drug design Small molecules Natural product chemistry Helical peptides Cell permeability Protein-protein recognition

Editors and affiliations

  • Gilles Goetz
    • 1
  1. 1.Hit Discovery and OptimizationPfizer R&DGrotonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9503-5
  • Online ISBN 978-1-4939-9504-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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