RNA Interference and Cancer Therapy

Methods and Protocols

  • Lekha Dinesh Kumar

Part of the Methods in Molecular Biology book series (MIMB, volume 1974)

Table of contents

  1. Front Matter
    Pages i-xiii
  2. Xing Fei Tan, Wei Xuan Teo, George W. Yip
    Pages 21-30
  3. Phillip A. Angart, Kwasi Adu-Berchie, Rebecca J. Carlson, Daniel B. Vocelle, Christina Chan, S. Patrick Walton
    Pages 41-56
  4. Anna A. Egorova, Marianna A. Maretina, Anton V. Kiselev
    Pages 57-68
  5. Dian-Jang Lee, Ernst Wagner
    Pages 83-98
  6. Daniel F. Costa, Can Sarisozen, Vladimir P. Torchilin
    Pages 99-109
  7. Yu-Lin Su, Piotr Swiderski, Guido Marcucci, Marcin Kortylewski
    Pages 141-150
  8. Inbal Hazan-Halevy, Daniel Rosenblum, Srinivas Ramishetti, Dan Peer
    Pages 151-159
  9. A. James Mixson, Qixin Leng, Szu-Ting Chou, Martin C. Woodle
    Pages 161-180
  10. Hitesh Kulhari, Ashok K. Jangid, David J. Adams
    Pages 195-201
  11. Claudia Tortiglione, Jesús M de la Fuente
    Pages 203-214
  12. Deep Pooja, Ramakrishna Sistla
    Pages 215-221
  13. Lei Kang, Zachary T. Rosenkrans, Weibo Cai
    Pages 223-231
  14. Syed Sultan Beevi, Naveen Kumar Tangudu, Vinod Kumar Verma, Lekha Dinesh Kumar
    Pages 245-263
  15. Rebaz Ahmed, Narsireddy Amreddy, Anish Babu, Anupama Munshi, Rajagopal Ramesh
    Pages 265-290
  16. Kamil Rahme, Jianfeng Guo, Justin D. Holmes
    Pages 291-301
  17. Joshua A. McCarroll, George Sharbeen, Maria Kavallaris, Phoebe A. Phillips
    Pages 329-353
  18. Daniel P. Feldmann, Steven Jones, Kirk Douglas, Anthony F. Shields, Olivia M. Merkel
    Pages 355-369
  19. Serena Tommasini-Ghelfi, Andrew Lee, Chad A. Mirkin, Alexander H. Stegh
    Pages 371-391
  20. Back Matter
    Pages 409-416

About this book


This comprehensive volume collects a repertoire of techniques for the adoption and exploitation of RNA interference (RNAi) as a fertile strategy to develop the bio-drugs of future in the vital field of cancer research. Exploring the immense ‘bench to bedside’ potential of RNAi as a therapeutic molecule, the book focuses many of its chapters on nanoparticle-based targeted deliveries, including aptamers, as well as techniques for using RNAi technology to combat various cancers in preclinical studies. Each of the 26 chapters is authored by the pioneers in the respective areas and thus provides a practical and empirical account of the techniques that could be used as benchmark tools in the area of cancer research. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and essential, RNA Interference and Cancer Therapy: Methods and Protocols provides the necessary guidance for both novice and professional researchers who intend to discover and innovate newer means of using RNAi technology to combat cancer, one of the greatest scourges of human health.


Cancer treatment Therapeutic tools RNAi-based strategies Bio-drugs Drug development Targeted delivery Nanoparticles

Editors and affiliations

  • Lekha Dinesh Kumar
    • 1
  1. 1.Cancer Biology, CSIR-Centre for Cellular and Molecular BiologyHyderabadIndia

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9219-5
  • Online ISBN 978-1-4939-9220-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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