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Nuclear Receptors

Methods and Experimental Protocols

  • Mostafa Z. Badr

Part of the Methods in Molecular Biology book series (MIMB, volume 1966)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Gisela I. Mazaira, Nadia R. Zgajnar, Cecilia M. Lotufo, Cristina Daneri-Becerra, Jeffrey C. Sivils, Olga B. Soto et al.
    Pages 1-5
  3. Aisling Smyth, Martina Gogarty, Daniel Crean, Evelyn P. Murphy
    Pages 17-26
  4. Ashfaq Ali Mir, Kenneth Allen Dyar, Franziska Greulich, Fabiana Quagliarini, Céline Jouffe, Michaël Jean Hubert et al.
    Pages 39-70
  5. Borbala Katona, Ahmed Ibrahim, Mårten Sundberg, Cecilia Williams
    Pages 79-99
  6. Teddy Kamata, Chun-Song Yang, Kasey Jividen, Adam Spencer, Natalia Dworak, Luke T. Oostdyk et al.
    Pages 107-124
  7. Gisela I. Mazaira, Mario D. Galigniana
    Pages 125-135
  8. C. Trent Brewer, Jonathan Low, Taosheng Chen
    Pages 137-149
  9. Dongwook Yeo, Chounghun Kang, Li Li Ji
    Pages 151-161
  10. Jenni Küblbeck, Paavo Honkakoski
    Pages 163-173
  11. Jia Yue Shi, Rachel E. Rubino, Christopher J. B. Nicol
    Pages 203-210
  12. Syed F. Hassnain Waqas, Grace Ampem, Tamás Röszer
    Pages 211-224
  13. Grace Ampem, Tamás Röszer
    Pages 225-236
  14. Jihong Chen, Hongsheng Liang, Aili Gao, Qiao Li
    Pages 247-252
  15. Rebecca L. Frkic, John B. Bruning
    Pages 253-260
  16. Merilin Al Sharif, Ivanka Tsakovska, Petko Alov, Vessela Vitcheva, Antonia Diukendjieva, Ilza Pajeva
    Pages 261-289
  17. Back Matter
    Pages 313-314

About this book

Introduction

This volume presents valuable techniques for studying the class of ligand-activated transcription factors known as nuclear receptors. After a brief overview of the history of the field, chapters cover methods to detect the receptors and their mRNAs in various tissues, protocols to characterize nuclear receptor modulators and activities, their signaling and roles in certain pathogenesis, molecular modeling of nuclear receptor-ligand interactions, as well as the utility of informatics in the field of nuclear receptors. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and cutting-edge, Nuclear Receptors: Methods and Experimental Protocols seeks to aid researchers working toward furthering our understanding of these vital receptors and their role in numerous pathological conditions.

Keywords

Drug discovery NR ligands Ligand-activated transcription factors Receptor signaling Molecular modeling Modulators Drug development

Editors and affiliations

  • Mostafa Z. Badr
    • 1
  1. 1.School of PharmacyUniversity of Missouri-Kansas CityKansas CityUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-1-4939-9195-2
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-9194-5
  • Online ISBN 978-1-4939-9195-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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