The Hippo Pathway

Methods and Protocols

  • Alexander Hergovich

Part of the Methods in Molecular Biology book series (MIMB, volume 1893)

Table of contents

  1. Front Matter
    Pages i-xiv
  2. The Hippo Pathway: Drosophila Genetics Lead the Way

  3. Molecular and Cell Biology Studies of the Hippo Pathway

    1. Front Matter
      Pages 87-87
    2. Franziska Haderk, Victor Olivas, Trever G. Bivona
      Pages 89-95
    3. Valentina Rausch, Carsten G. Hansen
      Pages 97-106
    4. Nathan M. Kingston, Andrew M. Tilston-Lunel, Julia Hicks-Berthet, Xaralabos Varelas
      Pages 107-113
    5. Maria Chatzifrangkeskou, Eric O’Neill
      Pages 115-119
    6. Diana Zindel, Claire Vol, Odile Lecha, Isabelle Bequignon, Merve Bilgic, Marion Vereecke et al.
      Pages 153-166
    7. Yoichi Asaoka, Hitoshi Morita, Hiroko Furumoto, Carl-Philipp Heisenberg, Makoto Furutani-Seiki
      Pages 167-181
    8. Ryan J. Quinton, Neil J. Ganem
      Pages 203-214
    9. Nina Reuven, Matan Shanzer, Yosef Shaul
      Pages 215-236
  4. Structure Biology and Biochemistry to Study the Hippo Pathway

    1. Front Matter
      Pages 237-237
    2. Sun-Yong Kim, Toshio Hakoshima
      Pages 273-280
    3. Rui Chen, Steven W. Plouffe, Kun-Liang Guan
      Pages 281-287
    4. Niamh A. O’Driscoll, David Matallanas
      Pages 289-304
    5. Marta Gomez, Yavuz Kulaberoglu, Alexander Hergovich
      Pages 319-331
  5. The Hippo Pathway and Mouse Models

    1. Front Matter
      Pages 333-333
    2. Lixin Hong, Yuxi Li, Qingxu Liu, Qinghua Chen, Lanfen Chen, Dawang Zhou
      Pages 353-370
  6. Back Matter
    Pages 371-374

About this book


This detailed book covers numerous expert methodologies to examine Hippo signaling on the structural, molecular, cellular, and organismal level. Beginning with a section on Drosophila genetics, the volume continues with parts exploring molecular and cell biological studies of the Hippo pathway, the use of structural biology and biochemistry, and a brief look at the Hippo pathway in mouse models. Written for the highly successful Methods in Molecular Biology series, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.  

Comprehensive and practical, The Hippo Pathway: Methods and Protocols equips newcomers and specialists alike with key methodologies to accurately define the status of Hippo signaling in their experimental settings.


Tissue homeostasis Structural biology Drosophila genetics Hippo signaling YAP/TAZ Organ growth

Editors and affiliations

  • Alexander Hergovich
    • 1
  1. 1.Cancer InstituteUniversity College LondonLondonUK

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-8909-6
  • Online ISBN 978-1-4939-8910-2
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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