Bone Morphogenetic Proteins

Methods and Protocols

  • Melissa B. Rogers

Part of the Methods in Molecular Biology book series (MIMB, volume 1891)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Jessica Ann Cottrell, Donya Burgess, Sarah Michaels, Melissa B. Rogers
    Pages 1-8
  3. Clement D. Marshall, Elizabeth A. Brett, Alessandra L. Moore, Derrick C. Wan, Michael T. Longaker
    Pages 9-18
  4. Austin Dickerson, Eleanor L. Davis, Corinne Sonnet, Alan R. Davis, Elizabeth A. Olmsted-Davis
    Pages 19-28
  5. Luke D. Hutchinson, Polyxeni Bozatzi, Thomas Macartney, Gopal P. Sapkota
    Pages 29-35
  6. Cathy Savage-Dunn, Ryan J. Gleason, Jun Liu, Richard W. Padgett
    Pages 51-73
  7. Brian G. Stultz, Deborah A. Hursh
    Pages 75-89
  8. Luok Wen Yong, Iryna Kozmikova, Jr-Kai Yu
    Pages 91-114
  9. Hyung-Seok Kim, Autumn McKnite, Jan L. Christian
    Pages 115-133
  10. Joseph Zinski, Francesca Tuazon, Yan Huang, Mary Mullins, David Umulis
    Pages 135-154
  11. Melissa LaBonty, Pamela C. Yelick
    Pages 155-163
  12. Maaike Alkema, Marie-José Goumans, Boudewijn P. T. Kruithof
    Pages 191-200
  13. Marcelo Rocha Marques, Jean-Denis Bénazet
    Pages 201-219
  14. Teresa Dinter, Geoffrey A. Bocobo, Paul B. Yu
    Pages 221-233
  15. Deboleena Kanjilal, Jessica Ann Cottrell
    Pages 235-245
  16. Salin A. Chakkalakal, Eileen M. Shore
    Pages 247-255
  17. Jenna Newman, Rachel NeMoyer, Andrew Zloza, John Langenfeld
    Pages 257-262
  18. Back Matter
    Pages 263-265

About this book


This volume provides methods to study bone morphogenetic proteins (BMPs) and BMP modulators in cell culture, in both invertebrate and vertebrate animal models, and for therapeutic applications. Chapters guide the reader in the use of primary and immortalized cell lines, methodologies that exploit transcription and receptor mechanisms, newly developed animal models using nematodes, flies, amphioxus, frogs, zebrafish, and genetically engineered mice, and pre-clinical approaches to understanding BMP function in bone regeneration, heterotopic ossification, and cancers. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls.

  Authoritative and cutting-edge, Bone Morphogenetic Proteins: Methods and Protocols aims to ensure successful results in the further study of this vital field.


miRNAs RNA binding proteins Post-translational processing Mycoplasma-induced BMP2 Drosophila

Editors and affiliations

  • Melissa B. Rogers
    • 1
  1. 1.New Jersey Medical SchoolRutgers Biomedical and Health SciencesNewarkUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-8903-4
  • Online ISBN 978-1-4939-8904-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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