Targeting Notch in Cancer

From the Fruit Fly to the Clinic

  • Lucio Miele
  • Spyros Artavanis-Tsakonas

Table of contents

  1. Front Matter
    Pages i-viii
  2. Kelly L. Arnett, Tom C. M. Seegar, Stephen C. Blacklow
    Pages 1-33
  3. Jyothi Vijayaraghavan, Barbara A. Osborne
    Pages 35-53
  4. Takumi Kumai, Paulo C. Rodriguez
    Pages 127-151
  5. Emily Gerry, Vivek Singh, Tian-Li Wang
    Pages 153-173
  6. Lisa M. Minter
    Pages 175-197
  7. Catherine Hoofd, Vincenzo Giambra, Andrew P. Weng
    Pages 199-225
  8. Jeffrey C. Bloodworth, Clodia Osipo
    Pages 227-240
  9. Sara L. Sinicropi-Yao, Michael J. Koenig, David P. Carbone
    Pages 241-276
  10. Cristina Cossetti, Alberto Gualtieri, Silvia Pomella, Elena Carcarino, Rossella Rota
    Pages 277-312
  11. Anna Bigas, Cristina Ruiz-Herguido, Rosa Aligué, Lluís Espinosa
    Pages 313-332
  12. Lluís Espinosa, Erika López-Arribillaga, Oriol Bachs, Anna Bigas
    Pages 333-352
  13. Judy S. Crabtree
    Pages 353-380
  14. Back Matter
    Pages 381-389

About this book


The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets.

Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected


Cancer Drosophila Notch Notch TAN-1 chromosome 7

Editors and affiliations

  • Lucio Miele
    • 1
  • Spyros Artavanis-Tsakonas
    • 2
  1. 1.Department of GeneticsLouisiana State University Health Sciences CenterNew OrleansUSA
  2. 2.Department of Cell BiologyHarvard Medical SchoolBostonUSA

Bibliographic information

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