© 2019

Methionine Dependence of Cancer and Aging

Methods and Protocols

  • Robert M. Hoffman

Part of the Methods in Molecular Biology book series (MIMB, volume 1866)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Robert M. Hoffman, Peter H. Stern, Dennis W. Coalson, C. Douglas Wallace, Richard W. Erbe
    Pages 13-26
  3. Robert M. Hoffman, Richard W. Erbe
    Pages 27-36
  4. Elena Strekalova, Dmitry Malin, Harisha Rajanala, Vincent L. Cryns
    Pages 61-73
  5. Robert M. Hoffman, Yasunori Hoshiya, Weiyan Guo
    Pages 75-81
  6. Robert M. Hoffman, Peter H. Stern
    Pages 83-94
  7. Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Shigeo Yagi, Tomoaki Takakura et al.
    Pages 107-131
  8. Robert M. Hoffman, Shuya Yano, Kentaro Igarashi
    Pages 133-148
  9. Robert M. Hoffman, Takashi Murakami, Kei Kawaguchi, Kentaro Igarashi, Yuying Tan, Shukuan Li et al.
    Pages 149-161
  10. Robert M. Hoffman, Demetrius M. Kokkinakis, Eugene P. Frenkel
    Pages 163-171
  11. Robert M. Hoffman, Kenji Miki, Waddah Al-Refaie, Mingxu Xu, Yuying Tan
    Pages 173-197
  12. Robert M. Hoffman, Zhijian Yang, Yuying Tan, Qinghong Han, Shukuan Li, Shigeo Yagi
    Pages 211-229
  13. Robert M. Hoffman, Yuying Tan, Shukuan Li, Qinghong Han, Jorge Zavala Sr, Jorge Zavala Jr
    Pages 231-242
  14. V. S. Pokrovsky, N. Yu. Anisimova, D. Zh. Davydov, S. V. Bazhenov, N. V. Bulushova, G. B. Zavilgelsky et al.
    Pages 243-261
  15. Robert M. Hoffman
    Pages 263-266
  16. Robert M. Hoffman, David Machover
    Pages 279-284
  17. Robert M. Hoffman, Qinghong Han, Kei Kawaguchi, Shukuan Li, Yuying Tan
    Pages 311-322
  18. Back Matter
    Pages 323-329

About this book


This book explores the methionine dependence of cancer and its effects on aging, a great story of science that is not widely known. The chapters in this book describe the discovery of methionine dependence of cancer; the molecular basis for the increased methionine demand of cancer cells and tumors; the clinical application of methionine dependence of cancer in PET imaging with [11C]methionine; the development of methioninases as cancer drugs; the anti-aging and anti-diabetes effects of methionine restriction; and the future of targeting methionine in the body for the elimination of cancer and for the extension of a healthy life-span. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Cutting-edge and thorough, Methionine Dependence of Cancer and Aging: Methods and Protocols is an important resource for researchers and scientists wishing to pursue this exciting and vital area of study."


methioninases Warburg effect METase rMETase polyethylene glycol

Editors and affiliations

  • Robert M. Hoffman
    • 1
  1. 1.AntiCancer, Inc.San DiegoUSA

Bibliographic information

  • Book Title Methionine Dependence of Cancer and Aging
  • Book Subtitle Methods and Protocols
  • Editors Robert M. Hoffman
  • Series Title Methods in Molecular Biology
  • Series Abbreviated Title Methods Molecular Biology
  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2019
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Hardcover ISBN 978-1-4939-8795-5
  • eBook ISBN 978-1-4939-8796-2
  • Series ISSN 1064-3745
  • Series E-ISSN 1940-6029
  • Edition Number 1
  • Number of Pages XII, 329
  • Number of Illustrations 46 b/w illustrations, 34 illustrations in colour
  • Topics Cancer Research
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Oncology & Hematology
Consumer Packaged Goods