Cancer Epigenetics for Precision Medicine

Methods and Protocols

  • Ramona G. Dumitrescu
  • Mukesh Verma

Part of the Methods in Molecular Biology book series (MIMB, volume 1856)

Table of contents

  1. Front Matter
    Pages i-x
  2. Early Epigenetic Changes and New Epigenetic Targets in Different Types of Cancers

    1. Front Matter
      Pages 1-1
    2. Ramona G. Dumitrescu
      Pages 3-17
    3. Lulu Farhana, Hirendra Nath Banerjee, Mukesh Verma, Adhip P. N. Majumdar
      Pages 35-55
    4. Dongho Kim, Duk-Hwan Kim
      Pages 57-85
    5. Nataly Cruz-Rodriguez, Alba L. Combita, Jovanny Zabaleta
      Pages 87-101
    6. Ovidiu Balacescu, Ramona G. Dumitrescu, Catalin Marian
      Pages 103-117
  3. Contributing Environmental Factors to Epigenetic Changes Leading to Cancer Development

    1. Front Matter
      Pages 119-119
    2. Nicoleta Andreescu, Maria Puiu, Mihai Niculescu
      Pages 121-139
    3. Gabriela Riscuta, Dan Xi, Dudith Pierre-Victor, Pamela Starke-Reed, Jag Khalsa, Linda Duffy
      Pages 141-156
    4. Ramona G. Dumitrescu
      Pages 157-172
    5. Edyta Reszka, Shanbeh Zienolddiny
      Pages 173-201
    6. Irina Daniela Florea, Christina Karaoulani
      Pages 203-218
    7. Krishna Banaudha, Vineet Kumar, Mukesh Verma
      Pages 233-243
  4. Methods Used in Cancer Epigenomics

    1. Front Matter
      Pages 245-245
    2. Hirendra Nath Banerjee, William Kahan, Vineet Kumar, Mukesh Verma
      Pages 255-267
    3. Matthew Poulin, Jeffrey Y. Zhou, Liying Yan, Toshi Shioda
      Pages 283-296
  5. Edyta Reszka, Shanbeh Zienolddiny
    Pages C1-C1
  6. Back Matter
    Pages 297-298

About this book


This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.


transcriptomic epigenomic high-throughput genomic cancer therapy tumors proteomic

Editors and affiliations

  • Ramona G. Dumitrescu
    • 1
  • Mukesh Verma
    • 2
  1. 1.Kelly Government SolutionsBethesdaUSA
  2. 2.Division of Cancer Control and Population SciencesNational Cancer Institute, National Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-8750-4
  • Online ISBN 978-1-4939-8751-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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