Copy Number Variants

Methods and Protocols

  • Derek M.¬†Bickhart

Part of the Methods in Molecular Biology book series (MIMB, volume 1833)

Table of contents

  1. Front Matter
    Pages i-x
  2. Yang Zhou, Derek M. Bickhart, George E. Liu
    Pages 49-59
  3. John Wiedenhoeft, Alexander Schliep
    Pages 83-93
  4. Kai Ye, Li Guo, Xiaofei Yang, Eric-Wubbo Lamijer, Keiran Raine, Zemin Ning
    Pages 95-105
  5. Ruoyan Chen, Yu Lung Lau, Wanling Yang
    Pages 107-114
  6. Nathan Fortier, Gabe Rudy, Andreas Scherer
    Pages 115-127
  7. Zechen Chong, Ken Chen
    Pages 129-141
  8. Sergii Ivakhno, Eric Roller
    Pages 155-168
  9. Lingyang Xu, Liu Yang, Derek M. Bickhart, JunYa Li, George E. Liu
    Pages 179-186
  10. Saki Chan, Ernest Lam, Michael Saghbini, Sven Bocklandt, Alex Hastie, Han Cao et al.
    Pages 193-203
  11. Lingyang Xu, Liu Yang, Derek M. Bickhart, JunYa Li, George E. Liu
    Pages E1-E1
  12. Back Matter
    Pages 205-206

About this book


This volume offers detailed step-by-step instructions to allow beginners and experts alike to run appropriate copy number variants (CNV) detection software on a dataset of choice and discern between false positive noise and true positive CNV signals. Chapters guide readers through single nucleotide polymorphism (SNP) chips, optical mapping assembly techniques, and current open-source programs specializing in CNV detection.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Copy Number Variants: Methods and Protocols aims to provide guidance to Bioinformaticians and Molecular Biologists who are interested in identifying copy number variants (CNV) with a wide variety of experimental media



Editors and affiliations

  • Derek M.¬†Bickhart
    • 1
  1. 1.Research Microbiologist/BioinformaticianUSDA ARS DFRCMadisonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-8665-1
  • Online ISBN 978-1-4939-8666-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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