Multiple Myeloma

Methods and Protocols

  • Christoph Heuck
  • Niels Weinhold

Part of the Methods in Molecular Biology book series (MIMB, volume 1792)

Table of contents

  1. Front Matter
    Pages i-x
  2. Tina Smets, Frederik Stevenaert, HC Adams 3rd, Greet Vanhoof
    Pages 47-54
  3. Anja Seckinger, Tomi Bähr-Ivacevic, Vladimir Benes, Dirk Hose
    Pages 97-115
  4. Santiago Barrio, Matteo DáVia, Laura Bruins, Thorsten Stühmer, Torsten Steinbrunn, Max Bittrich et al.
    Pages 117-128
  5. Sridurga Mithraprabhu, Andrew Spencer
    Pages 129-145
  6. Owen W. Stephens, Tobias Meißner, Niels Weinhold
    Pages 147-155
  7. Alboukadel Kassambara, Jerome Moreaux
    Pages 157-166
  8. Anitha Thomas, Shyam M. Garg, Rebecca A. G. De Souza, Eric Ouellet, Grace Tharmarajah, Dave Reichert et al.
    Pages 193-203
  9. Jessica R. Hoffman, Ennio Tasciotti, Roberto Molinaro
    Pages 205-214
  10. Christoph Heuck, Niels Weinhold
    Pages E3-E3
  11. Back Matter
    Pages 215-216

About this book


This volume provides a thorough guide of the study of multiple myeloma (MM)—from sample acquisition to the performance of molecular tests, and also discusses difficulties that arise during quality control and interpretation of results. The chapters in this book cover topics, such as next-generation-flow-based methods for detection of minimal residual disease and circulating tumor cells; Cytometry by Time-of-Flights (CyTOF); a droplet digital PCR approach for finding contamination in patients’ samples; genome-wide investigation of the methylation and hydroxymethylation status of cytosines; and a microfluidic approach for creating nanoparticles. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Cutting-edge and comprehensive, Multiple Myeloma: Methods and Protocols is a valuable resource for molecular scientists and laboratory supervisors working with MM samples, and any investigator conducting studies in this field.


Flowcytometry FISH signaling pathways PCR Microarray

Editors and affiliations

  • Christoph Heuck
    • 1
  • Niels Weinhold
    • 2
  1. 1.Janssen R&DSpring HouseUSA
  2. 2.The Myeloma InstituteUniversity of Arkansas for Medical ScienceLittle RockUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7864-9
  • Online ISBN 978-1-4939-7865-6
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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