Huntington’s Disease

  • Sophie V. Precious
  • Anne E. Rosser
  • Stephen B. Dunnett

Part of the Methods in Molecular Biology book series (MIMB, volume 1780)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Nasim F. Mehrabi, Malvindar K. Singh-Bains, Henry J. Waldvogel, Richard L. M. Faull
    Pages 1-16
  3. Eleanna Stamatakou, Ye Zhu, David C. Rubinsztein
    Pages 17-29
  4. Charlene Geater, Sarah Hernandez, Leslie Thompson, Virginia B. Mattis
    Pages 41-73
  5. Anjalika Chongtham, Brett Barbaro, Tomas Filip, Adeela Syed, Weijian Huang, Marianne R. Smith et al.
    Pages 75-96
  6. Pamela P. Farshim, Gillian P. Bates
    Pages 97-120
  7. Stephen B. Dunnett, Simon P. Brooks
    Pages 121-141
  8. Elissa J. Donzis, Sandra M. Holley, Carlos Cepeda, Michael S. Levine
    Pages 163-177
  9. Natalia Kosior, Blair R. Leavitt
    Pages 179-207
  10. Mariah J. Lelos, Stephen B. Dunnett
    Pages 209-220
  11. Julien Flament, Philippe Hantraye, Julien Valette
    Pages 285-301
  12. Sarah Gregory, Rachael I. Scahill, Geraint Rees, Sarah Tabrizi
    Pages 303-328
  13. Filipe B. Rodrigues, Lauren M. Byrne, Edward J. Wild
    Pages 329-396
  14. Korrapati V. Sathyasaikumar, Carlo Breda, Robert Schwarcz, Flaviano Giorgini
    Pages 397-413
  15. I. Luísa Ferreira, Catarina Carmo, Luana Naia, Sandra I. Mota, A. Cristina Rego
    Pages 415-442
  16. Gabriel Vachey, Nicole Déglon
    Pages 463-481
  17. Thomas Massey, Branduff McAllister, Lesley Jones
    Pages 483-495
  18. Roger M. Lane, Anne Smith, Tiffany Baumann, Marc Gleichmann, Dan Norris, C. Frank Bennett et al.
    Pages 497-523
  19. Mari Savolainen, Dwaine Emerich, Jeffrey H. Kordower
    Pages 525-547
  20. Victoria H. Roberton, Anne E. Rosser, Anne-Marie McGorrian, Sophie V. Precious
    Pages 573-583
  21. Lindsay Fraser, Kevin Bruce, John M. Campbell, Paul A. De Sousa
    Pages 607-629
  22. Back Matter
    Pages 631-642

About this book


This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.


Mutant huntingtin Neurodegenerative disease Neuropathology Animal models Gene manipulation Genetic disease

Editors and affiliations

  • Sophie V. Precious
    • 1
  • Anne E. Rosser
    • 2
  • Stephen B. Dunnett
    • 3
  1. 1.Brain Repair GroupCardiff UniversityCardiffUnited Kingdom
  2. 2.Brain Repair GroupCardiff UniversityCardiffUnited Kingdom
  3. 3.Brain Repair GroupCardiff UniversityCardiffUnited Kingdom

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7824-3
  • Online ISBN 978-1-4939-7825-0
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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