Peptide Self-Assembly

Methods and Protocols

  • Bradley L. Nilsson
  • Todd M. Doran

Part of the Methods in Molecular Biology book series (MIMB, volume 1777)

Table of contents

  1. Front Matter
    Pages i-xv
  2. Fundamental Methods for Characterizing Peptide Self-Assembly

    1. Front Matter
      Pages 1-1
    2. Danting Huang, Benjamin C. Hudson, Yuan Gao, Evan K. Roberts, Anant K. Paravastu
      Pages 23-68
    3. Jean-Marie Ruysschaert, Vincent Raussens
      Pages 69-81
    4. Angelo Bella, Michael Shaw, Emiliana De Santis, Maxim G. Ryadnov
      Pages 83-100
    5. Ronald Wetzel, Saketh Chemuru, Pinaki Misra, Ravi Kodali, Smita Mukherjee, Karunakar Kar
      Pages 121-144
    6. Xiaomeng Lu, Regina M. Murphy
      Pages 145-158
    7. Judith J. Mittag, Joachim O. Rädler, Jennifer J. McManus
      Pages 159-171
  3. Methods for the Preparation of Functional Self-Assembled Peptide Biomaterials

    1. Front Matter
      Pages 173-173
    2. Dan Yuan, Junfeng Shi, Ning Zhou, Bing Xu
      Pages 175-180
    3. Nina Dinjaski, Wenwen Huang, David L. Kaplan
      Pages 181-192
    4. Jin Mo Koo, Hao Su, Yi-An Lin, Honggang Cui
      Pages 193-207
    5. Carolina Mora Solano, Yi Wen, Huifang Han, Joel H. Collier
      Pages 233-248
    6. C. Brent Chesson, Rojelio Elias Alvarado, Jai S. Rudra
      Pages 249-259
    7. Zsofia Lengyel, Caroline M. Rufo, Ivan V. Korendovych
      Pages 261-270
    8. Dawei Xu, Louis DeRidder, Brendan Elmore, He Dong
      Pages 271-281
    9. Mhairi M. Harper, Michael L. Connolly, Laura Goldie, Eleanore J. Irvine, Joshua E. Shaw, Vineetha Jayawarna et al.
      Pages 283-303
  4. Methods Related to Preparing, Characterizing and Inhibiting Pathological Amyloid Peptide Self-Assembly

    1. Front Matter
      Pages 305-305
    2. Tiernan T. O’Malley, Sara Linse, Dominic M. Walsh
      Pages 307-320
    3. Hyewon Chung, Elliot J. Crooks, Martine Ziliox, Steven O. Smith
      Pages 321-330
    4. Samuel A. Kotler, Ayyalusamy Ramamoorthy
      Pages 331-338
    5. Ravinder Malik, Jing Di, Gayatri Nair, Aida Attar, Karen Taylor, Edmond Teng et al.
      Pages 369-386
    6. Baiping Ren, Rundong Hu, Mingzhen Zhang, Yonglan Liu, Lijian Xu, Binbo Jiang et al.
      Pages 429-447
  5. Back Matter
    Pages 449-452

About this book


This volume details methods and protocols on b-sheet assemblies and collagen. Divided into three parts chapters focus on expanding use of solid-state NMR as a powerful method to enhance structural understanding of self-assembled peptide materials, methods for the design, synthesis, and application of self-assembled peptide materials, and structural and mechanistic analyses of pathological amyloid systems that provide novel ways to assess function of the various possible aggregates as well to determine how the structure of these materials correlates to function/dysfunction in the biological context. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

 Authoritative and cutting-edge, Computational Drug Discovery and Design aims to capture modern methods that span the breadth of the exciting and expanding field of peptide self-assembly.


protein self-assembly phenomena extracellular matrix proteins amyloid pathologies solid-state NMR spectroscopic

Editors and affiliations

  • Bradley L. Nilsson
    • 1
  • Todd M. Doran
    • 2
  1. 1.Department of ChemistryUniversity of RochesterRochesterUSA
  2. 2.Department of Medicinal Chemistry, Institute for Translational NeuroscienceUniversity of MinnesotaMinneapolisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7809-0
  • Online ISBN 978-1-4939-7811-3
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
Industry Sectors
Consumer Packaged Goods