Polycystic Kidney Disease

Translating Mechanisms into Therapy

  • Benjamin D. Cowley, Jr.
  • John J. Bissler

Table of contents

  1. Front Matter
    Pages i-xiii
  2. PKD: Genes and Proteins

  3. PKD: Mechanisms of Disease

    1. Front Matter
      Pages 67-67
    2. Alison Grazioli, Patricia Outeda, Terry Watnick
      Pages 69-86
    3. Dawn E. Landis, Scott J. Henke, Bradley K. Yoder
      Pages 87-110
    4. James C. Harms, Cheng Jack Song, Michal Mrug
      Pages 111-129
  4. ADPKD: Clinical Features

    1. Front Matter
      Pages 131-131
    2. Young-Hwan Hwang, Moumita Barua, Anna McNaught, Korosh Khalili, York Pei
      Pages 133-142
    3. Cristian Riella, Peter G. Czarnecki, Theodore I. Steinman
      Pages 155-169
  5. ADPKD: Clinical Trials and Emerging Therapies

    1. Front Matter
      Pages 207-207
    2. Maria V. Irazabal, Vicente E. Torres
      Pages 219-227
    3. Ronald D. Perrone, Osama W. Amro
      Pages 243-262
  6. Back Matter
    Pages 263-273

About this book


This comprehensive guide to polycystic kidney disease captures the growing knowledge of this common, potentially-fatal and hereditary disease.  The first two sections of the book provide an overview of PKD gene structures, mutations and pathophysiologic mechanisms.  This is followed by chapters focused on PKD’s clinical features, including renal and extrarenal manifestations, and appropriate management of patients.  The final section covers current clinical trials and emerging therapies in PKD.  Authored by experts in the field, this book provides the clinician and researcher with critical information on basic and translational science and clinical approaches in one concise resource.


Clinical Features of PKD Emergicing Therapies for PKD End Stage Renal Disease Genetic Disease Pathophysiologic Mechanisms of PKD Polycystic Kidney Disease

Editors and affiliations

  • Benjamin D. Cowley, Jr.
    • 1
  • John J. Bissler
    • 2
  1. 1.John Gammill Professor in Polycystic Kidney Disease, Chief, Section of Nephrology and Hypertension, Department of MedicineUniversity of Oklahoma Health Sciences CenterOklahoma CityUSA
  2. 2.Federal Express Chair of Excellence, Chief, Division of Nephrology, Department of Pediatrics, Director, Tuberous Sclerosis Center of Excellence at Le Bonheur Children’s Hospital, Medical Director, Nephrology St. Jude Children’s Research HospitalUniversity of Tennessee Health Science Center, Children’s Foundation Research CenterMemphisUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Springer, New York, NY
  • eBook Packages Medicine Medicine (R0)
  • Print ISBN 978-1-4939-7782-6
  • Online ISBN 978-1-4939-7784-0
  • Buy this book on publisher's site
Industry Sectors
Health & Hospitals
Internal Medicine & Dermatology