Computational Systems Biology

Methods and Protocols

  • Tao┬áHuang

Part of the Methods in Molecular Biology book series (MIMB, volume 1754)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Keyi Long, Lei Cai, Lin He
    Pages 1-13
  3. Hong Zhang, Lin He, Lei Cai
    Pages 15-27
  4. Xing Chen, Gang Ni, Kai He, Zhao-Li Ding, Gui-Mei Li, Adeniyi C. Adeola et al.
    Pages 29-44
  5. Jun Li, Renzhong Liu, Cuihong Huang, Shifu Chen, Mingyan Xu
    Pages 45-65
  6. Shifu Chen, Ming Liu, Yanqing Zhou
    Pages 67-95
  7. Michelle Chang, Lin He, Lei Cai
    Pages 97-108
  8. Xiang-Tian Yu, Tao Zeng
    Pages 109-135
  9. Guangyong Zheng, Tao Huang
    Pages 137-154
  10. Chao Zhang, Caoqi Fan, Jingbo Gan, Ping Zhu, Lei Kong, Cheng Li
    Pages 167-181
  11. Xiang-tian Yu, Lu Wang, Tao Zeng
    Pages 183-204
  12. Yi Xiong, Xiaolei Zhu, Hao Dai, Dong-Qing Wei
    Pages 223-234
  13. Jing Lu, Dong Lu, Zunyun Fu, Mingyue Zheng, Xiaomin Luo
    Pages 247-264
  14. Jing Cheng, Wenxian Lan, Guangyong Zheng, Xianfu Gao
    Pages 265-292
  15. Beiyuan Fan, Junbo Wang, Ying Xu, Jian Chen
    Pages 293-309
  16. Yungang Xu, Xiaobo Zhou
    Pages 327-374
  17. Yi-yi Wang, Bing-di Xie
    Pages 375-386
  18. Back Matter
    Pages 415-417

About this book


This volume introduces the reader to the latest experimental and bioinformatics methods for DNA sequencing, RNA sequencing, cell-free tumour DNA sequencing, single cell sequencing, single-cell proteomics and metabolomics. Chapters detail advanced analysis methods, such as Genome-Wide Association Studies (GWAS), machine learning, reconstruction and analysis of gene regulatory networks and differential coexpression network analysis, and gave a practical guide for how to choose and use the right algorithm or software to handle specific high throughput data or multi-omics data. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and cutting-edge, Computational Systems Biology: Methods and Protocols aims to ensure successful results in the further study of this vital field. 


Cancer Cell Line Encyclopedia Genotype-Tissue Expression Python RNA-sequencing Chip-Seq

Editors and affiliations

  • Tao┬áHuang
    • 1
  1. 1.Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7716-1
  • Online ISBN 978-1-4939-7717-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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