Biomarkers for Alzheimer’s Disease Drug Development

  • Robert Perneczky

Part of the Methods in Molecular Biology book series (MIMB, volume 1750)

Table of contents

  1. Front Matter
    Pages i-xv
  2. The Need for Alzheimer’s Disease Biomarkers

  3. Innovative Approaches to Cerebrospinal Fluid Biomarker Discovery

    1. Front Matter
      Pages 67-67
    2. Angelo Palmigiano, Angela Messina, Rosaria Ornella Bua, Rita Barone, Luisa Sturiale, Mario Zappia et al.
      Pages 75-91
    3. Johannes Denk, Holger Jahn
      Pages 93-107
  4. Novel Blood-Based Biomarkers

    1. Front Matter
      Pages 109-109
    2. Jonathan Vogelgsang, Jens Wiltfang, Hans W. Klafki
      Pages 111-124
    3. Raúl González-Domínguez, Álvaro González-Domínguez, Ana Sayago, Ángeles Fernández-Recamales
      Pages 125-137
    4. Filippo Baldacci, Simone Lista, Sid E. O’Bryant, Roberto Ceravolo, Nicola Toschi, Harald Hampel et al.
      Pages 139-155
  5. Magnetic Resonance Imaging Methods

    1. Front Matter
      Pages 157-157
    2. Stefan Holiga, Ahmed Abdulkadir, Stefan Klöppel, Juergen Dukart
      Pages 159-163
    3. Carles Falcon, Grégory Operto, José Luis Molinuevo, Juan Domingo Gispert
      Pages 165-184
    4. Ismini C. Mainta, Maria I. Vargas, Sara Trombella, Giovanni B. Frisoni, Paul G. Unschuld, Valentina Garibotto
      Pages 185-200
  6. Molecular Imaging Approaches

    1. Front Matter
      Pages 201-201
    2. Tessa Timmers, Bart N. M. van Berckel, Adriaan A. Lammertsma, Rik Ossenkoppele
      Pages 221-229
  7. Neuropathology

    1. Front Matter
      Pages 253-253
    2. Giuseppe Astarita, Matteo Stocchero, Giuseppe Paglia
      Pages 255-269
    3. Steve Gentleman, Alan King Lun Liu
      Pages 271-279
  8. Genomic Methods

  9. Preclinical Research

    1. Front Matter
      Pages 321-321
    2. Cornelius K. Donat, Nazanin Mirzaei, Sac-Pham Tang, Paul Edison, Magdalena Sastre
      Pages 323-339
  10. Related Concepts: Cognitive Testing and Advanced Analytics

  11. Cornelius K. Donat, Nazanin Mirzaei, Sac-Pham Tang, Paul Edison, Magdalena Sastre
    Pages E1-E1
  12. Back Matter
    Pages 371-372

About this book


This volume aims to build a new generation of experts with a broader understanding of key topics in the Alzheimer’s disease field. Chapters guide readers through innovative approaches to the discovery of novel biomarkers in cerebrospinal fluid, innovation in blood-based biomarkers, a comprehensive overview of magnetic resonance imaging and molecular imaging approaches and their value for developing drugs for Alzheimer’s disease, cutting-edge developments in neuropathology and their relevance for Alzheimer’s disease trials, novel genomic strategies for biomarker development, and related topics including neuropsychological testing and advanced analytical methods.Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.


Authoritative and cutting-edge, Biomarkers for Alzheimer's Disease Drug Development aims to ensure successful results in the further study of this vital field. 


Alzheimer’s disease (AD) cerebrospinal fluid blood-based biomarkers magnetic resonance imaging neuropathology biomarker development

Editors and affiliations

  • Robert Perneczky
    • 1
  1. 1.Department of Psychiatry and PsychotherapyLudwig-Maximilians-Universität MünchenMunichGermany

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7703-1
  • Online ISBN 978-1-4939-7704-8
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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