Drug-Induced Liver Toxicity

  • Minjun Chen
  • Yvonne Will

Part of the Methods in Pharmacology and Toxicology book series (MIPT)

Table of contents

  1. Front Matter
    Pages i-xx
  2. Introduction

    1. Front Matter
      Pages 1-1
  3. In Silico and Modeling Approaches

    1. Front Matter
      Pages 19-19
    2. Shraddha Thakkar, Minjun Chen, Huixiao Hong, Zhichao Liu, Hong Fang, Weida Tong
      Pages 45-59
    3. Lilia Fisk, Nigel Greene, Russ Naven
      Pages 61-76
    4. Huixiao Hong, Jieqiang Zhu, Minjun Chen, Ping Gong, Chaoyang Zhang, Weida Tong
      Pages 77-100
    5. Christina Battista, Brett A. Howell, Scott Q. Siler, Paul B. Watkins
      Pages 101-121
  4. In Vitro Technologies

    1. Front Matter
      Pages 123-123
    2. Zhen Ren, Si Chen, Baitang Ning, Lei Guo
      Pages 151-177
    3. Min Wei Wong, Chris S. Pridgeon, Constanze Schlott, B. Kevin Park, Christopher E. P. Goldring
      Pages 199-212
    4. Chase P. Monckton, Salman R. Khetani
      Pages 213-248
    5. Monicah A. Otieno, Jinping Gan, William Proctor
      Pages 249-261
    6. Mathieu Porceddu, Nelly Buron, Pierre Rustin, Bernard Fromenty, Annie Borgne-Sanchez
      Pages 283-300
  5. Methodologies Applied in Regulatory Science

    1. Front Matter
      Pages 365-365
    2. John Senior, Ted Guo
      Pages 411-429
    3. Bereket Tesfaldet, Gyorgy Csako, Tejas Patel, Md Shamsuzzaman, Eileen Navarro Almario
      Pages 431-457
    4. S. Christopher Jones, Cindy Kortepeter, Allen D. Brinker
      Pages 459-474
  6. Methodologies for Clinical Studies

  7. New Emerging Technologies

    1. Front Matter
      Pages 595-595
    2. Julian Krauskopf, Jos C. Kleinjans, Theo M. de Kok
      Pages 597-610
    3. Marije Niemeijer, Steven Hiemstra, Steven Wink, Wouter den Hollander, Bas ter Braak, Bob van de Water
      Pages 611-625
    4. J. Gerry Kenna, John C. Waterton, Andreas Baudy, Aleksandra Galetin, Catherine D. G. Hines, Paul Hockings et al.
      Pages 627-651 Open Access
  8. Back Matter
    Pages 653-667

About this book


This book provides a comprehensive view of the methodologies used for the study of liver toxicity encountered throughout the whole life cycle of a drug, from drug discovery, to clinical trial, post-marketing, and even clinical practice. Organized into six sections, the first section introduces the mechanisms contributing to drug-induced liver toxicity.  The second and third section explore in silico and in vitro approaches used to help mitigate hepatotoxicity liability at the early stages of drug development. The fourth section describes methodologies applied in regulatory processes, including preclinical studies, clinical trials, and post-marketing surveillance. The fifth section discusses clinical hepatotoxicity. Emerging technologies are examined in the final section. As a volume in the Methods in Pharmacology and Toxicology series, chapters include the kind of expert advice that will lead to optimal results. 

Authoritative and practical, Drug-Induced Liver Toxicity serves all those who aim to improve assessment and understanding of hepatotoxic potentials of new medications and marketed drugs.

Chapter 30 is open access under a CC BY 4.0 license via 


Acute liver failure Drug development Regulatory processes Preclinical and clinical studies Hepatotoxins Hepatotoxicity DILI

Editors and affiliations

  • Minjun Chen
    • 1
  • Yvonne Will
    • 2
  1. 1.Division of Bioinformatics and Biostatistics, National Center for Toxicological ResearchU.S. Food and Drug AdministrationJeffersonUSA
  2. 2.Drug Safety Research and DevelopmentPfizer Inc.GrotonUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media, LLC, part of Springer Nature 2018
  • Publisher Name Humana, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7676-8
  • Online ISBN 978-1-4939-7677-5
  • Series Print ISSN 1557-2153
  • Series Online ISSN 1940-6053
  • Buy this book on publisher's site
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