The Biology of Mammalian Spermatogonia

  • Jon M. Oatley
  • Michael D. Griswold

Table of contents

  1. Front Matter
    Pages i-xi
  2. Spermatogenesis in Mammals

  3. Postnatal Development of the Spermatogonial Population

    1. Front Matter
      Pages 21-21
  4. Spermatogonial Stem Cells

    1. Front Matter
      Pages 65-65
  5. Spermatogonial Differentiation

    1. Front Matter
      Pages 131-131
    2. My-Thanh Beedle, Cathryn A. Hogarth, Michael D. Griswold
      Pages 133-146
    3. Rod T. Mitchell, Laura O’Hara, Lee B. Smith
      Pages 147-178
  6. Genome Integrity of Spermatogonia

    1. Front Matter
      Pages 179-179
    2. Tegan S. A. Horan, Caroline V. Sartain, Patricia A. Hunt
      Pages 205-223
    3. Denise G. Lanza, Jason D. Heaney
      Pages 225-267
  7. Tools to Study Spermatogonial Biology

    1. Front Matter
      Pages 269-269
    2. Hiroshi Kubota, Ralph L. Brinster
      Pages 271-300
    3. Takehiko Ogawa
      Pages 301-312
  8. Therapeutic Potentials and Applications of Spermatogonia

    1. Front Matter
      Pages 313-313
    2. Sherin David, Kyle E. Orwig
      Pages 315-341
    3. Raquel González, Lin Tang, Ina Dobrinski
      Pages 343-377
  9. Back Matter
    Pages 379-387

About this book


This book provides a resource of current understandings about various aspects of the biology of spermatogonia in mammals. Considering that covering the entire gamut of all things spermatogonia is a difficult task, specific topics were selected to provide foundational information that will be useful for seasoned researchers in the field of germ cell biology as well as investigators entering the area.

Looking to the future, the editors predict that the foundational information provided in this book -- combined with the advent of new tools and budding interests in use of non-rodent mammalian models -- will produce another major advance in knowledge regarding the biology of spermatogonia over the next decade. In particular, we anticipate that the core molecular machinery driving different spermatogonial states in most, if not all, mammals will be described fully, the extrinsic signals emanating from somatic support cell populations to influence spermatogonial functions will become fully known, and the capacity to derive long-term cultures of SSCs and transplant the population to regenerate spermatogenesis and fertility will become a reality for higher order mammals. 


Spermatozoa Fertility Mammals Stem cells Spermatogonia Spermatogenesis

Editors and affiliations

  • Jon M. Oatley
    • 1
  • Michael D. Griswold
    • 2
  1. 1.Centre for Reproductive Biology, School of Molecular BiosciencesWashington State UniversityPullmanUSA
  2. 2.School of Molecular BiosciencesWashington State UniversityPullmanUSA

Bibliographic information

Industry Sectors
Health & Hospitals