Cancer Systems Biology

Methods and Protocols

  • Louise von Stechow

Part of the Methods in Molecular Biology book series (MIMB, volume 1711)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Systems Biology of the Cancer Genetic and Epigenetic Landscape

    1. Front Matter
      Pages 1-1
    2. Heng Pan, Olivier Elemento
      Pages 27-53
    3. Andliena Tahiri, Miriam R. Aure, Vessela N. Kristensen
      Pages 55-81
    4. James Campbell, Colm J. Ryan, Christopher J. Lord
      Pages 83-99 Open Access
  3. Systems Analyses of Signaling Networks in Cancer Cells

    1. Front Matter
      Pages 101-101
    2. Jakob Wirbel, Pedro Cutillas, Julio Saez-Rodriguez
      Pages 103-132 Open Access
  4. Systems Analysis of Cancer Cell Metabolism

    1. Front Matter
      Pages 165-165
    2. Leslie R. Euceda, Tonje H. Haukaas, Tone F. Bathen, Guro F. Giskeødegård
      Pages 167-189
  5. Systems Biology of Metastasis and Tumor/Microenvironment Interactions

    1. Front Matter
      Pages 191-191
    2. David A. Hormuth II, Stephanie L. Eldridge, Jared A. Weis, Michael I. Miga, Thomas E. Yankeelov
      Pages 225-241
    3. Binbin Chen, Michael S. Khodadoust, Chih Long Liu, Aaron M. Newman, Ash A. Alizadeh
      Pages 243-259
    4. Aaron DeWard, Rebecca J. Critchley-Thorne
      Pages 261-273
  6. Modeling Drug Responses in Cancer Cells

    1. Front Matter
      Pages 275-275
    2. Neel S. Madhukar, Olivier Elemento
      Pages 277-296
    3. Junfeng Zhu, Hamidreza Badri, Kevin Leder
      Pages 297-331
    4. Liye He, Evgeny Kulesskiy, Jani Saarela, Laura Turunen, Krister Wennerberg, Tero Aittokallio et al.
      Pages 351-398
  7. Back Matter
    Pages 399-402

About this book


This book comprises protocols describing systems biology methodologies and computational tools, offering a variety of ways to analyze different types of high-throughput cancer data. Chapters give an overview over data types available in large-scale data repositories and state-of-the-art methods used in the field of cancer systems biology.  Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Authoritative and practical, Cancer Systems Biology : Methods and Protocols aims to ensure successful results in the further study of this vital field.

The chapters "Identifying Genetic Dependencies in Cancer by Analyzing siRNA Screens in Tumor Cell Line Panels", "Perseus: A Bioinformatics Platform for Integrative Analysis of Proteomics Data in Cancer Research" and "Phosphoproteomics-based Profiling of Kinase Activities in Cancer Cells" are available open access under a CC BY 4.0 license via


somatic mutational network Bioinformatics Mass Spectrometry lipidomics metastatic lesion proteomics

Editors and affiliations

  • Louise von Stechow
    • 1
  1. 1.NNF Center for Protein ResearchUniversity of CopenhagenCopenhagenDenmark

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media LLC 2018
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7492-4
  • Online ISBN 978-1-4939-7493-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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