Genomic Mosaicism in Neurons and Other Cell Types

  • José María Frade
  • Fred H. Gage

Part of the Neuromethods book series (NM, volume 131)

Table of contents

  1. Front Matter
    Pages i-xvi
  2. Introduction

    1. Front Matter
      Pages 1-1
    2. Alexej Abyzov, Alexander E. Urban, Flora M. Vaccarino
      Pages 3-24
  3. Aneuploidy and Ploidy Variation

    1. Front Matter
      Pages 25-25
    2. Yuri B. Yurov, Svetlana G. Vorsanova, Ilia V. Soloviev, Alexei M. Ratnikov, Ivan Y. Iourov
      Pages 27-41
    3. Noelia López-Sánchez, Iris Patiño-Parrado, José María Frade
      Pages 57-80
    4. Thomas Arendt, Birgit Belter, Martina K. Brückner, Uwe Ueberham, Markus Morawski, Attila Tarnok
      Pages 81-106
  4. DNA Copy Number Variation

    1. Front Matter
      Pages 107-107
    2. Margaret B. Wierman, Ian E. Burbulis, William D. Chronister, Stefan Bekiranov, Michael J. McConnell
      Pages 109-131
    3. Luming Zhou, Robert A. Palais, Yotam Ardon, Carl T. Wittwer
      Pages 143-162
    4. Jennifer L. Hazen, Michael A. Duran, Ryan P. Smith, Alberto R. Rodriguez, Greg S. Martin, Sergey Kupriyanov et al.
      Pages 163-185
  5. LINE-1 Retrotransposition

    1. Front Matter
      Pages 187-187
    2. Miki Bundo, Tadafumi Kato, Kazuya Iwamoto
      Pages 209-217
    3. Francisco J. Sanchez-Luque, Sandra R. Richardson, Geoffrey J. Faulkner
      Pages 219-251
    4. Patrick J. Reed, Meiyan Wang, Jennifer A. Erwin, Apuã C. M. Paquola, Fred H. Gage
      Pages 253-268
  6. Genetic and Genomic Mosaicism in Aging and Disease

    1. Front Matter
      Pages 269-269
    2. Grasiella A. Andriani, Cristina Montagna
      Pages 271-298
    3. Carlo Sala Frigerio, Mark Fiers, Thierry Voet, Bart De Strooper
      Pages 361-378
  7. Back Matter
    Pages 379-382

About this book


This volume presents methods for the analysis of genomic variability in vertebrate neurons and broadens our knowledge in the ways we understand the brain and its neurons. The chapters in this book are divided into 5 parts, and cover the following topics: principles and approaches for discovery of somatic mosaicism in the brain, aneuploidy and ploidy variation, DNA copy number variation, LINE-1 retrotransposition, and genetic and genomic mosaicism in aging and disease. In Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory.

Cutting-edge and authoritative, Genomic Mosaicism in Neurons and Other Cell Types is a valuable resource for learning about the latest techniques for the analysis of genome and genetic mosaicism in vertebrate neurons.


FISH neuronal aneuploidy Flow cytometric cytometry somatic L1 insertions

Editors and affiliations

  • José María Frade
    • 1
  • Fred H. Gage
    • 2
  1. 1.Department of Molecular, Cellular and Developmental NeurobiologyCajal Institute (IC-CSIC)MadridSpain
  2. 2.Biological Studies and Laboratory of GeneticsThe Salk InstituteLa JollaUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media LLC 2017
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-7279-1
  • Online ISBN 978-1-4939-7280-7
  • Series Print ISSN 0893-2336
  • Series Online ISSN 1940-6045
  • Buy this book on publisher's site
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