Oncogene-Induced Senescence

Methods and Protocols

  • Mikhail A.┬áNikiforov

Part of the Methods in Molecular Biology book series (MIMB, volume 1534)

Table of contents

  1. Front Matter
    Pages i-xi
  2. Anna Bianchi-Smiraglia, Brittany C. Lipchick, Mikhail A. Nikiforov
    Pages 1-15
  3. Lena Lau, Gregory David
    Pages 17-30
  4. Michael Shtutman, Bey-Dih Chang, Gary P. Schools, Eugenia V. Broude
    Pages 31-39
  5. Dorothy N. Y. Fan, Clemens A. Schmitt
    Pages 41-52
  6. Amaresh C. Panda, Kotb Abdelmohsen, Myriam Gorospe
    Pages 79-87
  7. Hengrui Zhu, Linh Le, Hsin-Yao Tang, David W. Speicher, Rugang Zhang
    Pages 127-137
  8. Rabii Ameziane-El-Hassani, Corinne Dupuy
    Pages 139-145
  9. Mikhail A. Nikiforov, Donna S. Shewach
    Pages 165-173
  10. Andrew Joselow, Darren Lynn, Tamara Terzian, Neil F. Box
    Pages 175-184
  11. Kwan-Hyuck Baek, Sandra Ryeom
    Pages 185-198
  12. Mekayla Storer, William M. Keyes
    Pages 199-210
  13. Back Matter
    Pages 219-220

About this book


This book offers in a single volume a unique collection of the state-of-the-art experimental procedures utilized for the induction, detection, and modeling of this complex cellular program of oncogene-induced senescence. The book encompasses protocols for studying this multi-step program in human specimens and a variety of experimental models including cultured mammalian cells, laboratory mice, and Drosophila melanogaster, as well as offering a description of high throughput approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Authoritative and practical, Oncogene-Induced Senescence: Methods and Protocols represents a valuable asset for a wide audience of medical oncologists and researchers in the fields of oncology, molecular and cellular biology, biochemistry, and animal development.


Senescent cells Phenotypes Cellular processes Oncology Oncoproteins

Editors and affiliations

  • Mikhail A.┬áNikiforov
    • 1
  1. 1.Department of Cell Stress BiologyRoswell Park Cancer InstituteBuffaloUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2017
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-6668-4
  • Online ISBN 978-1-4939-6670-7
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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