Frontiers in Cancer Research

Evolutionary Foundations, Revolutionary Directions

  • Carlo C. Maley
  • Mel Greaves

Table of contents

  1. Front Matter
    Pages i-xiv
  2. John W. Pepper
    Pages 17-30
  3. Andrea Sottoriva, Simon Tavaré
    Pages 31-42
  4. Lauren M. F. Merlo
    Pages 43-59
  5. Douglas E. Brash
    Pages 61-98
  6. Trevor A. Graham, Simon J. Leedham
    Pages 99-112
  7. Joshua D. Schiffman, Richard M. White, Trevor A. Graham, Qihong Huang, Athena Aktipis
    Pages 135-176
  8. Mel Greaves, C. Athena Aktipis
    Pages 195-215
  9. Aurora M. Nedelcu, Aleah F. Caulin
    Pages 217-246
  10. Back Matter
    Pages 257-258

About this book


This is the ideal book for anyone contemplating starting a career in, or shifting their career to, studying the dynamics that drive cancer progression and its response to therapy. Topics include the theory and population genetics of cancers, genetic diversity within tumors (intra-tumor heterogeneity), understanding how mutant clones expand in tissues, the role of cancer stem cells in the dynamics of tumors, the evolution of metastasis, and how to improve cancer therapy by addressing the evolution of cancers in response to our interventions. There are also chapters on the patterns of cancer susceptibility in humans due to a mismatch between our modern environment and the environment in which our ancestors evolved, as well as a chapter on the evolution of cancer suppression mechanisms that have evolved in different species, particularly the large long-lived animals like elephants and whales that are better at suppressing cancers than humans.  

This book serves as a primer on the evolutionary and ecological theory of cancer- the framework upon which all the details of cancer may be hung. It is ideal for oncologists and cancer researchers interested in evolutionary theory, and evolutionary biologists and ecologists interested in gaining insights into cancer development and prevention.  


Cancer Ecology Evolution Population Genetics Oncology

Editors and affiliations

  • Carlo C. Maley
    • 1
  • Mel Greaves
    • 2
  1. 1.Biodesign Institute, School of Life SciencesArizona State UniversityTempeUSA
  2. 2.Division of Molecular PathologyThe Institute of Cancer ResearchLondonUnited Kingdom

Bibliographic information

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