Vaccine Adjuvants

Methods and Protocols

  • Christopher B. Fox

Part of the Methods in Molecular Biology book series (MIMB, volume 1494)

Table of contents

  1. Front Matter
    Pages i-xii
  2. Ruchi R. Shah, Kimberly J. Hassett, Luis A. Brito
    Pages 1-13
  3. Mallesh Beesu, Hari Prasad Kokatla, Sunil A. David
    Pages 29-44
  4. Alberto Fernández-Tejada, William E. Walkowicz, Derek S. Tan, David Y. Gin
    Pages 45-71
  5. Livia Brunner, Christophe Barnier-Quer, Nicolas Collin
    Pages 73-86
  6. Anna C. A. Yendo, Fernanda de Costa, Carla Kauffmann, Juliane D. Fleck, Grace Gosmann, Arthur G. Fett-Neto
    Pages 87-93
  7. Martin Valachovič, Ivan Hapala
    Pages 95-106
  8. Matthew N. Davies, Helene Pere, Iris Bosschem, Freddy Haesebrouck, Bram Flahou, Eric Tartour et al.
    Pages 107-125
  9. Yvonne Perrie, Elisabeth Kastner, Swapnil Khadke, Carla B. Roces, Peter Stone
    Pages 127-144
  10. Melissa C. Hanson, Darrell J. Irvine
    Pages 145-152
  11. Manjari Lal, Jessica White, Changcheng Zhu
    Pages 153-163
  12. Sachin G. Thakkar, Zhengrong Cui
    Pages 181-199
  13. Cristina Maria de Barros, Emad Ibrahim Wafa, Khanidtha Chitphet, Kawther Ahmed, Sean M. Geary, Aliasger K. Salem
    Pages 201-213
  14. Michelle Y. Chan, Timothy S. Dutill, Ryan M. Kramer
    Pages 215-226
  15. Manvi Hasija, Anthony Sheung, Nausheen Rahman, Salvador F. Ausar
    Pages 227-238
  16. Michelle Y. Chan, Quinton M. Dowling, Sandra J. Sivananthan, Ryan M. Kramer
    Pages 239-252
  17. Alicia M. Schwartz, Michelle Y. Chan, Dawn M. Fedor, Sandra J. Sivananthan, Ryan M. Kramer
    Pages 273-283
  18. Michelle Y. Chan, Dawn M. Fedor, Tony Phan, Lucien Barnes V, Ryan M. Kramer
    Pages 285-294
  19. Jalil Hakimi, Sepideh Aboutorabian, Frederick To, Salvador F. Ausar, Nausheen Rahman, Roger H. Brookes
    Pages 295-304
  20. Back Matter
    Pages 369-372

About this book


This collection seeks to elucidate the practical methods necessary for successful adjuvant development, with a particular focus on the synthesis, formulation, manufacturing, and characterization aspects involved. Beginning with an overview and a case study, the book then delves into in silico design, chemical synthesis, biosynthesis, and/or purification from natural raw materials of specific adjuvant molecules, adjuvant formulation approaches, the analytical characterization of adjuvant formulations and adjuvant-containing vaccines, as well as the biological characterization of vaccine adjuvant activity, including in vitro and in vivo approaches, to measure innate and adaptive immune responses. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and authoritative, Vaccine Adjuvants: Methods and Protocols aims to facilitate vaccine adjuvant product development efforts, making them more accessible, manufacturable, and better characterized.


Human vaccines In silico design Adjuvant formulation Chemical synthesis Stressed stability Manufacture of vaccines

Editors and affiliations

  • Christopher B. Fox
    • 1
  1. 1.Infectious Disease Research InstituteSeattleUSA

Bibliographic information

  • DOI
  • Copyright Information Springer Science+Business Media New York 2017
  • Publisher Name Humana Press, New York, NY
  • eBook Packages Springer Protocols
  • Print ISBN 978-1-4939-6443-7
  • Online ISBN 978-1-4939-6445-1
  • Series Print ISSN 1064-3745
  • Series Online ISSN 1940-6029
  • Buy this book on publisher's site
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